Die Heliotherapie der Mycosis fungoides

Linser, K; Harnack, K

doi:10.1007/bf00486725

Cited by 7 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disease heterogeneity is a characteristic feature of CTCL [ 93 , 97 , 98 , 99 , 100 , 101 ] even at the single-cell level [ 100 , 102 , 103 , 104 , 105 ], which has hampered the unraveling of the etiology and pathogenesis and has been a complicating factor in the development of novel therapies. Although high sun exposure is associated with a lower risk of developing MF in Caucasians [ 106 ], and heliotherapy (the use of natural sunlight for the treatment—also named climate therapy) [ 107 , 108 ] and phototherapy/photochemotherapy have beneficial effects on CTCL skin lesions [ 84 , 109 ], other studies indicate that UV light is also a driver of mutations in CTCL [ 110 , 111 , 112 , 113 ]. Thus, a large part of the mutational burden in MF and SS was linked to a UV signature, which was also observed in CD4 + T cells isolated from the blood of SS patients [ 111 , 112 , 113 ].…”

Section: Overview Of Cutaneous T-cell Lymphomamentioning

confidence: 99%

Vitamin D in Cutaneous T-Cell Lymphoma

Ødum,

Geisler

2024

Cells

View full text Add to dashboard Cite

Cutaneous T-cell lymphoma (CTCL) is characterized by the proliferation of malignant T cells in inflamed skin lesions. Mycosis fungoides (MF)—the most common variant of CTCL—often presents with skin lesions around the abdomen and buttocks (“bathing suit” distribution), i.e., in skin areas devoid of sun-induced vitamin D. For decades, sunlight and vitamin D have been connected to CTCL. Thus, vitamin D induces apoptosis and inhibits the expression of cytokines in malignant T cells. Furthermore, CTCL patients often display vitamin D deficiency, whereas phototherapy induces vitamin D and has beneficial effects in CTCL, suggesting that light and vitamin D have beneficial/protective effects in CTCL. Inversely, vitamin D promotes T helper 2 (Th2) cell specific cytokine production, regulatory T cells, tolerogenic dendritic cells, as well as the expression of immune checkpoint molecules, all of which may have disease-promoting effects by stimulating malignant T-cell proliferation and inhibiting anticancer immunity. Studies on vitamin D treatment in CTCL patients showed conflicting results. Some studies found positive effects, others negative effects, while the largest study showed no apparent clinical effect. Taken together, vitamin D may have both pro- and anticancer effects in CTCL. The balance between the opposing effects of vitamin D in CTCL is likely influenced by treatment and may change during the disease course. Therefore, it remains to be discovered whether and how the effect of vitamin D can be tilted toward an anticancer response in CTCL.

show abstract

Section: Overview Of Cutaneous T-cell Lymphomamentioning

confidence: 99%

Vitamin D in Cutaneous T-Cell Lymphoma

Ødum,

Geisler

2024

Cells

View full text Add to dashboard Cite

show abstract

“…Heliotherapy, or phototherapy using natural sunlight, has been reported effective for treating diverse health issues (Metzger, 1926;Gardiner, 1915;Alpert, 2015) and skin conditions (Linser and Harnack, 1962;Buchholz, 1969;Körbler, 1967) since 1890s.…”

Section: Chapter I Introductionmentioning

confidence: 99%

Accurate surface ultraviolet radiation forecasting for clinical applications with deep neural network

Raksasat¹

View full text Add to dashboard Cite

Exposure to appropriate doses of UV radiation provides enormously health and medical treatment benefits including psoriasis. Typical hospital-based phototherapy cabinets contain a bunch of artificial lamps, either broad-band (main emission spectrum 280-360 nm, maximum 320 nm), or narrow-band UV B irradiation (main emission spectrum 310-315nm, maximum 311nm). For patients who cannot access phototherapy centers, sun-bathing, or heliotherapy, can be a safe and effective treatment alternative. However, as sunlight contains the full range of UV radiation (290-400 nm), careful sun-bathing supervised by photodermatologist based on accurate UV radiation forecast is vital to minimize potential adverse effects. Here, using 10-year UV radiation data collected at Nakhon Pathom, Thailand, we developed a deep learning model for UV radiation prediction which achieves around 10\% error for 24-hour forecast and 13-16\% error for 7-day up to 4-week forecast. Our approach can be extended to UV data from different geographical regions as well as various biological action spectra. This will become one of the key tools for developing national heliotherapy protocol in Thailand. Our model has been made available at github.com/cmb-chula/SurfUVNet.

show abstract

Strahlentherapie der Mycosis fungoides und des Sézary-Syndroms

Wiskemann¹

1987

Neue Entwicklungen in Der Dermatologie

View full text Add to dashboard Cite

Die Heliotherapie der Mycosis fungoides

Cited by 7 publications

References 0 publications

Vitamin D in Cutaneous T-Cell Lymphoma

Vitamin D in Cutaneous T-Cell Lymphoma

Accurate surface ultraviolet radiation forecasting for clinical applications with deep neural network

Strahlentherapie der Mycosis fungoides und des Sézary-Syndroms

Contact Info

Product

Resources

About