Die enzymatische Entstehung von Oxytyramin im Organismus und die physiologische Bedeutung der Dopadecarboxylase

Holtz, Peter; Credner, Karl; Koepp, W.

doi:10.1007/bf01860725

Cited by 163 publications

(12 citation statements)

References 10 publications

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“…This has been supported by most studies during the past decade [see reviews by Blaschko (33) and Kirshner (34)]. Of particular interest with respect to this report are the studies of Goodall and Kirshner (35) (39,40). In the brain of all mammalian slpecies studied, norepinephrine and dopamine are l)resent in approximately equal quantities (41).…”

supporting

confidence: 55%

Catecholamine Metabolism in a Functional Neural Tumor*

Greenberg¹,

Gardner²

1960

J. Clin. Invest.

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supporting

confidence: 55%

Catecholamine Metabolism in a Functional Neural Tumor*

Greenberg¹,

Gardner²

1960

J. Clin. Invest.

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“…3 Dopamine also raises blood pressure in the cat, 2 ' 4 but unlike the other catecholamines, it is a depressor in the guinea pig and rabbit. 4 The basis for such species differences is unknown.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dopamine in Man

Horwitz

Fox

Goldberg

1962

Circulation Research

140

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Dopamine, the biochemical precursor of norepinephrine, was infused intravenously into 11 normal subjects and 2 patients. Results of hemodynamic studies in 6 normal subjects indicated that dopamine increased cardiac output and stroke volume in all subjects. Arterial pressure also increased in all subjects with a predominant systolic pressure increment. Calculated vascular resistance decreased in 5 subjects and did not change in the other subject. Changes in heart rate were of small magnitude and were inconstant in direction. Left atrial pressure did not change in 2 patients at a time when substantial increments in cardiac output were produced by dopamine. Comparison of the doses of dopamine and norepinephrine calculated to produce equivalent increments in systolic pressure indicated that dopamine was 1/25 to 1/56 as potent as norepinephrine in this respect. Infusions of dopamine produced relatively small but consistent increments in blood glucose levels. It is concluded that the pharmacological actions of dopamine in man are different from those of epinephrine and norepinephrine. Because of its distinctive properties, dopamine may be useful in the treatment of patients with inadequate cardiac output.

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“…• Dopamine (3,4 dihydroxyphenylethylamine), a biochemical precursor of levarterenol and epinephrine, has been shown in previous studies in intact animals to be pressor in the eat, depressor in the rabbit and guinea pig, 1 and to have a variable, but predominantly pressor effect in the intact dog. 2 Dopamine has been shown by Fowler, Shabetai, and Holmes to produce contraction of the rabbit aortic strip in amounts above 4 fig.…”

mentioning

confidence: 99%

Direct Cardiac Effects of Dopamine

Holmes

Fowler

1962

Circulation Research

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The cardiac effects of dopaminie, an epinephrine precursor, were studied in 20 dog heart-lung preparations. In 8 uncontrolled rate preparations. dopamine, 0.5 to 1 mg., increased the heart rate an average of 18 pet cent. In controlled rate preparations. dopamine, 100 to 500 µg ., consistently increased ventricular contractile force, cardiac output and blood pressure; there was a consistent decrease of right and left atrial pressure. Comparable hemodynamic effects were produced by 1 to 5 µg . of levarterenol, except that the effects of dopamine tended to be of longer duration and were less likely to be followed by cardiac depression. It is concluded that doparnine has significant positive inotropic and chronotropic effects in the dog heart-lung preparation.

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Die enzymatische Entstehung von Oxytyramin im Organismus und die physiologische Bedeutung der Dopadecarboxylase

Cited by 163 publications

References 10 publications

Catecholamine Metabolism in a Functional Neural Tumor*

Catecholamine Metabolism in a Functional Neural Tumor*

Effects of Dopamine in Man

Direct Cardiac Effects of Dopamine

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