Die Empfehlungen der Swiss Memory Clinics für die Diagnostik der                Demenzerkrankungen

Bürge, Markus; Bieri, Gabriela; Brühlmeier, Matthias; Colombo, Françoise; Demonet, Jean-François; Felbecker, Ansgar; Georgescu, Dan; Gietl, Anton; Guevara, Andrea Brioschi; Jüngling, Freimut D.; Kirsch, Eberhard; Kressig, Reto W.; Kulic, Luka; Monsch, Andreas U.; Ott, Martin; Pihan, Hans; Popp, Julius; Rampa, Luca; Rüegger-Frey, Brigitte; Schneitter, Marianne; Unschuld, Paul G.; Gunten, Armin von; Weinheimer, Birte; Wiest, Roland; Savaskan, Egemen

doi:10.1024/1661-8157/a002948

Cited by 12 publications

(7 citation statements)

References 30 publications

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“…These findings appear to be at odds with guidelines from Germany (DGPPN and DGN 2017) and Switzerland, 24 for example, recommending the use of informant‐based questionnaires. We think that the discrepancy is best explained by the differences of setting in which questionnaires are used.…”

Section: Discussionmentioning

confidence: 83%

Informant Questionnaires in Dedicated Memory Clinics: How Much Do They Contribute?

Novak

Wyss

Lenouvel

et al. 2020

J American Geriatrics Society

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BACKGROUND/OBJECTIVES: The diagnostic process in a university memory clinic is based largely on cognitive testing. However, input from informants, acquired through interview or questionnaires, may significantly impact diagnosis. We sought to evaluate whether informant questionnaires for basic and instrumental activities of daily living, or for identifying progressive cognitive decline would improve diagnostic predictability of neurodegenerative disorders compared with either the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological test battery or the Mini-Mental State Examination score alone. DESIGN: Retrospective data analysis using logit models. SETTING: University hospital outpatient memory clinic. PARTICIPANTS: A total of 394 patients with dementia, mild cognitive impairment (MCI), depression, or subjective cognitive impairment were assessed. MEASUREMENTS: Bristol Activities of Daily Living Scale, Functional Activities Questionnaire, Informant Questionnaire on Cognitive Decline in the Elderly, and the Physical Self-Maintenance Scale questionnaires were obtained. Analyses through logit models were performed to predict outcome diagnoses, based on cognitive scores alone or in combination with one or more informant questionnaires. RESULTS: The four questionnaires were highly correlated (.31-.86). The addition of informant questionnaires improved diagnostic predictability between differential diagnoses of MCI and dementia, or dementia and depression. However, the misprediction rate was reduced by up to 6 percentage points only. Adding more than one questionnaire or all CERAD subtests instead of their sum score never improved prediction in regularized logit models to a clinically relevant extent. CONCLUSION: Although questionnaires contribute to a statistically better prediction of the outcome diagnosis, for some sets of differential diagnoses, the benefit may not be clinically pertinent when routine semistructured informant interviews are used by trained personnel. However, standardized assessment, particularly when patients are seen longitudinally, should not be underestimated.

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Section: Discussionmentioning

confidence: 83%

Informant Questionnaires in Dedicated Memory Clinics: How Much Do They Contribute?

Novak

Wyss

Lenouvel

et al. 2020

J American Geriatrics Society

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“…Measurements were performed in the memory clinics during the standard cognitive testing sessions for participants with MCI or MD. Each participant underwent an extensive cognitive screening procedure, including clinical and neuropsychological assessments, following international standards for dementia diagnosis [ 24 ]. During the same sessions, the informants completed the A-IADL-Q-SV German.…”

Section: Methodsmentioning

confidence: 99%

Cross-cultural adaptation and validation of the Amsterdam Instrumental Activities of Daily Living questionnaire short version German for Switzerland

Bruderer-Hofstetter

Dubbelman

Meichtry

et al. 2020

Health Qual Life Outcomes

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Background Instrumental Activities of Daily Living (IADL) limitations are associated with reduced health-related quality of life for people with mild cognitive impairment (MCI). For these people, the assessment of IADL is crucial to the diagnostic process, as well as for the evaluation of new interventions addressing MCI. The Amsterdam IADL Questionnaire Short Version (A-IADL-Q-SV) is an established assessment tool with good psychometric properties that has been shown to be robust to cultural differences in Western countries. The aims of this study were to: (1) cross-culturally adapt and validate the A-IADL-Q-SV for the German-speaking population of Switzerland; (2) investigate its cultural comparability; and (3) evaluate further psychometric properties. Methods The A-IADL-Q-SV German was pretested on clinicians and participants in a memory clinic setting. The psychometric properties and cultural comparability of the questionnaire were investigated in memory clinic settings including participants with MCI or mild dementia, as well as participants with normal cognition recruited from the community. Item response theory (IRT) was applied to investigate measurement invariance by means of differential item functioning to assess item bias. Additionally, the test–retest reliability on scale level, the construct validity through hypothesis testing and the discriminant validity of the A-IADL-Q-SV German were evaluated. Results Ninety-six informants of participants with normal cognition, MCI or mild dementia completed the A-IADL-Q-SV German. The basic assumptions for IRT scoring were met. No meaningful differential item functioning for culture was detected between the Swiss and Dutch reference samples. High test–retest reliability on scale level (ICC 0.93; 95% CI 0.9–0.96) was found. More than 75% of the observed correlations between the A-IADL-Q-SV German and clinical measures of cognition and functional status were found to be in the direction and of the magnitude hypothesized. The A-IADL-Q-SV German was shown to be able to discriminate between participants with normal cognition and MCI, as well as MCI and mild dementia. Conclusions The A-IADL-Q-SV German is a psychometrically robust measurement tool for a Swiss population with normal cognition, MCI and mild dementia. Thus, it provides a valuable tool to assess IADL functioning in clinical practices and research settings in Switzerland. Trial registration This study was registered retrospectively in July 2019 on ClinicalTrials.gov (NCT04012398).

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“…Je nach Symptomen liegt der Fokus auf neurologischen, (alters-)psychiatrischen oder geriatrischen Aspekten. Dementsprechend fordern auch die Empfehlungen der Swiss Memory Clinics die Einbindung verschiedener Disziplinen in die Abklärung neurokognitiver Störungen [7]. Eine neurologische Untersuchung sollte immer erfolgen, um neurologische Symptome zuverlässig zu erkennen und richtig einzuordnen.…”

Section: Demenzerkrankungen Aus Neurologischer Perspektive -Teilunclassified

“…Grundlage der klinischen Demenzdiagnostik sind die gründliche Erhebung der Eigen-und Fremdanamnese und die klinische Untersuchung [7]. Bei der Anamneseerhebung im Kontext kognitiver Störungen ist insbesondere die genaue Fremdanamnese durch das familiäre Umfeld von Bedeutung, auch um mögliche Persönlichkeits-oder Verhaltensänderungen zu er-fassen.…”

Section: Klinische Diagnostikunclassified

Demenzerkrankungen aus neurologischer Perspektive – Teil 1

Peters¹,

Pihan

Rouaud³

et al. 2023

Swiss Med Forum

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Die Empfehlungen der Swiss Memory Clinics für die Diagnostik der Demenzerkrankungen

Cited by 12 publications

References 30 publications

Informant Questionnaires in Dedicated Memory Clinics: How Much Do They Contribute?

Informant Questionnaires in Dedicated Memory Clinics: How Much Do They Contribute?

Cross-cultural adaptation and validation of the Amsterdam Instrumental Activities of Daily Living questionnaire short version German for Switzerland

Demenzerkrankungen aus neurologischer Perspektive – Teil 1

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