Die Dynamik des Herzens. Die Arbeitsweise des Herzens in ihrer Abhängigkeit von Spannung und Länge unter verschiedenen Arbeitsbedingungen

Evidence that digitalis influences contraction of the heart in man

“…Joseph (1913) states that in rabbits it requires only 28 mg. per kilo to increase contraction 12 per cent, but 50 mg. to bring about even a slight rise in blood pressure. Experiments dealing with this phase of the matter have recently been carried on by de Heer (1912), Straub (1914), Patterson, Piper and Starling (1914), and Wiggers and Katz (1922). Their experiments have shown that, although the systolic and diastolic cardiac volumes are both increased by raising the resistence offered by the aorta, the extent of the excursion in contraction is unchanged until the resistance to be oVercome passes a certain limit; and then there is a decrease in the height of the excursion.…”