This article highlights the territorial and functional embedding of world regions within a functionally differentiated world society, as well as the heterogeneity between different (local) practices of functional differentiation within world regions. Its argument proceeds in two steps. In a first step, it discusses the distinction between regional variations of functional differentiation versus regional variations within functional differentiation as an important tool in order to characterize specific variations of structural patterns. In a second step it turns to the Middle Eastern case, arguing that while at first glance this may be a candidate for a regional variation of functional differentiation, a closer look reveals that it has been characterized by a very specific variation within functional differentiation for quite a while. The article concludes by using these observations for some thoughts on the functional differentiation of world society more generally.