Die diffuse Sklerodermie und ihre Gefäßveränderung

Masugi, Matazo; Yä-Shu,

doi:10.1007/bf02595129

Cited by 55 publications

(17 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…focal but widespread occulsive renal vascular lesions. There is intimal hyperplasia of the interlobular and other small arteries marked by the deposition of a young connective tissue rich in acid mucopolysacharides, and fibrinoid necrosis of smaller arteries, afferent arterioles and glomerular tufts (2)(3)(4)(5)(6)(7)(8)(9). These changes appear to be indistinguishable from those encountered in nonsclerodermatous malignant hypertension, and in both conditions large amounts of fibrin have been detected in the fibrinoid material present in the walls of small vessels (10).…”

Section: Discussionmentioning

confidence: 99%

Hemodialysis and kidney transplantation for renal failure from scleroderma

Richardson

1973

Arthritis & Rheumatism

View full text Add to dashboard Cite

A merchant mariner had scleroderma with polyarthralgias and Raynaud's phenomenon for 15 years before the onset of rapidly progressive renal failure and severe hypertension. lntimal proliferation obliterated or greatly narrowed the lumina of renal arterioles. Initially, he tolerated periodic hemodialysis and efforts to reduce hypertension poorly but did better after bilateral nephrectomy. In the 18 months since successful kidney transplantation, arthralgias and Raynaud's phenomenon have disappeared and skin has become less tightly bound to underlying structures. Blood pressure remains normal. The grafted kidney shows no evidence of disease. For patients whose primary organ involvement by scleroderma is renal and whose other lesions are relatively stable, hemodialysis and kidney transplantation may provide additional years of reasonably comfortable life.Systemic sclerosis (scleroderma) is often associated with fulminating renal failure (1, 2). Changes in renal biopsies are indistinguishable from those of malignant hypertension even though the patient's blood pressure is not always greatly elevated (3). When renal failure occurs, the systemic nature of the primary disease ordinarily precludes expensive, scarce hemodialysis or kidney transplantation. We have successfully used both of these treatments in a man whose nonrenal manifestations of scleroderma seemed static and, in themselves, no bar to this therapy. CASE REPORTA 41 -year-old merchant seaman first experienced stiffness and aching of various joints in 1955. Early in 1958, at age 27, he noticed progressive tightening and thickening of the skin of his hands, and to a lesser extent, his forearms, face and feet. Histologic examination of a specimen of skin from a finger showed atrophy of the epidermis and appendages with swelling, hypertrophy and condensation of the collagen in the dermis. During his first hospitalization in October 1958, digitalis was prescribed for presumed mild congestive heart failure, manifested by bibasilar pulmonary rales and shortness of breath. The rales and dyspnea disappeared. At that time, blood pressure, chest x-ray, electrocardiogram, urinalysis, rate of phenolsulfonphthalein excretion, a Fishberg urine concentration test, serum creatinine and a renal biopsy all were normal.He was evaluated again in 1962. Skin changes showed no obvious progression. He complained of generalized aching in his joints and frequent attacks of painful blanching of his fingers in cold weather. Blood pressures, urinalyses and tests of renal function remained normal, as did a second renal biopsy. Agglutination tests for rheumatoid factor and tests for lupus erythematosus cells were negative. The digitalis was stopped without ill effect.In 1968 RICHARDSONwere normal. Raynaud's phenomenon and polyarthralgias had persisted over the years, and he had, more or less, adapted to them. Finger tips were sharply tapered. Shiny skin of hands and fingers, tightly hound to underlying structures, prevented a complete grip. Similar, hut less extensive, changes involved...

show abstract

Section: Discussionmentioning

confidence: 99%

Hemodialysis and kidney transplantation for renal failure from scleroderma

Richardson

1973

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…The formation of these cells, he suggested, was by fusion of adjoining cells which might or might not retain their cilia. Also, Masugi and Minami (1938) illustrated with clarity that the multinucleated cells in the respiratory mucosa have arisen from fusion of respiratory w epithelial cells.…”

Section: Resultsmentioning

confidence: 99%

The nature of multinucleated cells in the nasopharynx

Ali¹

1965

Journal of Clinical Pathology

View full text Add to dashboard Cite

SYNOPSIS Exfoliated multinucleated epithelial cells were shown to be present in nasopharyngeal smears from patients with moniliasis, tuberculous lesions, and non-specific chronic inflammations of the nasopharynx. Multinucleated cells found in the nasopharynx were cytologically similar to the so-called measles giant cells. Because of the association of these cells with a number of chronic inflammatory lesions, their function is probably related to phagocytosis. In evidence thereof, a few multinucleated cells, presumably of epithelial origin, showed phagocytosed particles within their cytoplasm. This view is also based on corroborative evidence given by a number of workers that epithelial cells in the respiratory mucosa and in the endometrium were shown to assume phagocytic functions comparable to those of free histiocytes.The epithelial lining of the human nasopharynx is composed of squamous, ciliated, and transitional epithelia. On average, approximately 40% of the nasopharyngeal mucosa is covered by pseudostratified columnar ciliated epithelium (Ali, 1965). The ciliated epithelium of the nasopharynx is, morphologically, similar to that lining the trachea and bronchi but has a tendency to be taller (Papanicolaou, 1954). The most characteristic cytological features of the ciliated columnar epithelium are the cilia, the heavy cuticular border, the round to oval granular nucleus, and the perinuclear cytoplasmic vacuolation. In addition, Papanicolaou (1954) The purpose of this communication is to report the frequent occurrence of multinucleated cells amongst other cells exfoliated from the human nasopharynx and to present the conditions associated with their presence. The genesis and the possible function of these cells are briefly discussed. MATERIALS AND METHODSNasopharyngeal swabs were taken from 138 patients suspected of having carcinoma of the nasopharynx and from 25 apparently healthy individuals. Two smears, on non-albuminised microscopic slides, were prepared from each swab and immediately fixed in equal parts of ether and 95 % alcohol. Nasopharyngeal biopsies were then taken from the 138 patients and nasopharyngeal mucosa from 100 necropsied medico-legal cases was utilized for the study of the normal histology.The cytological smears and paraffin sections of the biopsy and necropsy material were all stained with haematoxylin and eosin. The same stain was used for the histological and cytological preparation to facilitate comparison of various cell types in each.The cytological preparations were examined for the presence of malignant cells and each specimen was com-424 on 12 May 2018 by guest. Protected by copyright.

show abstract

“…Hekteon in 1897 reported a case in which the thyroid and the myocardium were involved and in which there were also changes in the pituitary. Masugi (1938) and Talbott and others (1939) recorded involvement of the kidneys. In 1943 Weiss and others thoroughly reviewed the subject of myocardial fibrosis in association with generalized scleroderma, and reported nine additional cases.…”

mentioning

confidence: 94%