Die Diagnostik und Therapie kutaner Lymphome erfordert spezielle klinische und dermatohistologische Kenntnisse

Klemke, Claus‐Detlev

doi:10.1111/ddg.13195

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Zumindest dermatohistologische Grundkenntnisse sind jedoch notwendig, um ein fundiertes Verständnis für die Klinik und Pathophysiologie dermatologischer Erkrankungen zu entwickeln. Zudem ist die klinisch‐pathologische Korrelation oftmals für die korrekte Diagnosestellung, wie bei kutanen Lymphomen, unabdingbar . Jeder erfahrene Dermatologe weiß den hohen Stellenwert des engen Kontakts und Austausches zwischen Klinikern und Dermatohistologen zu schätzen.…”

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Zukunftsperspektiven der Dermatohistologie in der Dermatologie

Mitteldorf

Géraud

2018

J Deutsche Derma Gesell

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Zukunftsperspektiven der Dermatohistologie in der Dermatologie

Mitteldorf

Géraud

2018

J Deutsche Derma Gesell

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Lymphoma, Hematological Neoplasia, and Metastases of the Oral Cavity

Klemke

Schmidt

2021

Diseases of the Oral Mucosa

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Diagnostik kutaner Lymphome

2017

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Primary cutaneous lymphomas can be diagnosed when the clinical symptoms, histology, immunohistology and molecular biological changes are characteristic of primary cutaneous T or B‑cell lymphomas; however, in many cases not all of the changes are typical of a primary cutaneous lymphoma especially in the early stages; therefore, the diagnosis of a primary cutaneous lymphoma can be a challenge. This is especially true for the Sézary syndrome, which can initially prove to be difficult to differentiate from reactive erythroderma; therefore, the main focus of this review is the diagnostics of Sézary syndrome. The review also summarizes the clinical heterogeneity and describes the classical histological and immunohistochemical changes for the diagnosis of Sézary syndrome. Recent data from different multicenter, international studies by the cutaneous lymphoma task force of the European Organisation for Research and Treatment of Cancer (EORTC) on dermatological alterations of the skin and the detection of Sézary cells in blood are addressed. The detection of Sézary cells in the blood still remains a challenge despite improved molecular boiological and cytogenetic characterization of tumor cells. The latest studies of the EORTC group particularly identified CD158k, MYC, MNT, DNM, TWIST1, EPHA4 and PLS3 as valuable markers for the differentiation of reactive erythroderma but which are not yet part of the standard diagnostics of Sézary syndrome. Further studies are required to see if these markers can be used in the routine clinical application.

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Die Diagnostik und Therapie kutaner Lymphome erfordert spezielle klinische und dermatohistologische Kenntnisse

Cited by 4 publications

References 8 publications

Zukunftsperspektiven der Dermatohistologie in der Dermatologie

Zukunftsperspektiven der Dermatohistologie in der Dermatologie

Lymphoma, Hematological Neoplasia, and Metastases of the Oral Cavity

Diagnostik kutaner Lymphome

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