Die Cortisol-Aufwachreaktion bei Patienten mit akuten und chronischen Rückenschmerzen

Sudhaus, Sigrid; Fricke, B.; Schneider, Stefan; Stachon, Axel; Klein, Harald; Düring, Monika von; Hasenbring, Monika

doi:10.1007/s00482-006-0521-4

Cited by 18 publications

(3 citation statements)

References 38 publications

(58 reference statements)

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“…However, a few studies found elevated cortisol levels [32–35], abnormal cortisol diurnal variations [36], and increased feedback sensitivity of the HPA axis [37] in certain chronic pain conditions, like fibromyalgia and chronic back pain. In contrast, several studies reported that the profiles of cortisol secretion in patients suffering with fibromyalgia [38, 39], chronic back pain [40, 41], or chronic temporomandibular disorders [42] did not differ from those in healthy controls. One possible explanation to these conflicting findings is that the HPA axis may be in the state of hyperactivity at the early stage of pain chronification, while, after long-term overt activity, the stress system reaches an exhausted state, thereby turning into the HPA axis hypoactivity [26].…”

Section: The Effect Of Stress Regulation On Painmentioning

confidence: 99%

The Role of Stress Regulation on Neural Plasticity in Pain Chronification

2016

Neural Plasticity

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Pain, especially chronic pain, is one of the most common clinical symptoms and has been considered as a worldwide healthcare problem. The transition from acute to chronic pain is accompanied by a chain of alterations in physiology, pathology, and psychology. Increasing clinical studies and complementary animal models have elucidated effects of stress regulation on the pain chronification via investigating activations of the hypothalamic-pituitary-adrenal (HPA) axis and changes in some crucial brain regions, including the amygdala, prefrontal cortex, and hippocampus. Although individuals suffer from acute pain benefit from such physiological alterations, chronic pain is commonly associated with maladaptive responses, like the HPA dysfunction and abnormal brain plasticity. However, the causal relationship among pain chronification, stress regulation, and brain alterations is rarely discussed. To call for more attention on this issue, we review recent findings obtained from clinical populations and animal models, propose an integrated stress model of pain chronification based on the existing models in perspectives of environmental influences and genetic predispositions, and discuss the significance of investigating the role of stress regulation on brain alteration in pain chronification for various clinical applications.

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Section: The Effect Of Stress Regulation On Painmentioning

confidence: 99%

The Role of Stress Regulation on Neural Plasticity in Pain Chronification

2016

Neural Plasticity

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“…Two studies, included in the review, analysed whether treatments for OA produced significant changes in cortisol levels in patients. Ortega et al 27 performed a case series of low quality showing that patients with knee OA had a significant increase in systemic cortisol levels after pelotherapy. Tonuk et al 36 conducted a cohort study of low quality examining the effect of the combined application of hot packs, US and TENS in patients with OA, showing an improvement of 29.1% in the WOMAC pain scores and a decrease of 21% in the cortisol levels after treatment, suggesting a positive association between cortisol changes and pain.…”

Section: Cortisol Oa Pain and Treatmentsmentioning

confidence: 99%

“…The analysed studies have contradictory results in relation to the levels of cortisol after receiving therapies, whereby in some cases the cortisol decreases and in others it increases. The two studies are not comparable because in Ortega et al 27 the post-treatment measurement was carried out a day after the last session of mud therapy, while in Tonuk et al 36 the blood sample was withdrawn following a 5 min resting period after the end of the therapy session.…”

Section: Cortisol Oa Pain and Treatmentsmentioning

confidence: 99%

Exploring the relationship between chronic pain and cortisol levels in subjects with osteoarthritis: results from a systematic review of the literature

Villafañe

Bertozzi

Drago

et al. 2020

Osteoarthritis and Cartilage

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Objective: Several reports in the literature have identified an association between cortisol levels and the presence of chronic pain in conditions such as rheumatoid arthritis, low back pain or whiplash. In contrast, few have examined the association of cortisol and pain in people with osteoarthritis (OA). The purpose of this systematic review was to verify the association between cortisol and pain in the OA population. Design: The databases MEDLINE, CINAHL, EMBASE were searched systematically for human studies written in English up to December 2018. Two researchers screened titles and abstracts against predefined inclusion criteria; a third resolved discrepancies. Articles were included if they measured the cortisol levels in adults with pain in the OA population. Methodological quality was assessed using Methodological Index for non-randomized Studies (MINORS) score. Results: Seven studies reporting on 415 patients were included in this review. The MINORS scale yielded mean scores of 8.6 of 16 and 17.5 of 24, for the cohort and caseecontrol studies respectively. In general, the studies were of poor quality. A discrepancy of noteworthy associations between cortisol level comparison and pain was found. Conclusions: This study shows that there is a discrepancy in the relationship between cortisol and pain dependent on how and when cortisol is measured. Evidence from three low-quality studies suggest increased cortisol levels in patients with pain but the conclusions have a high risk of bias. It was not possible to make a quantitative analysis comparing the relationship between cortisol and pain in the OA population.

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Fertilization

Marcello

Singaravelu

Singson

2012

Advances in Experimental Medicine and Biology

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Fertilization-the fusion of gametes to produce a new organism-is the culmination of a multitude of intricately regulated cellular processes. In Caenorhabditis elegans, fertilization is highly efficient. Sperm become fertilization competent after undergoing a maturation process during which they become motile, and the plasma membrane protein composition is reorganized in preparation for interaction with the oocyte. The highly specialized gametes begin their interactions by signaling to one another to ensure that fertilization occurs when they meet. The oocyte releases prostaglandin signals to help guide the sperm to the site of fertilization, and sperm secrete a protein called major sperm protein (MSP) to trigger oocyte maturation and ovulation. Upon meeting one another in the spermatheca, the sperm and oocyte fuse in a specific and tightly regulated process. Recent studies are providing new insights into the molecular basis of this fusion process. After fertilization, the oocyte must quickly transition from the relative quiescence of oogenesis to a phase of rapid development during the cleavage divisions of early embryogenesis. In addition, the fertilized oocyte must prevent other sperm from fusing with it as well as produce an eggshell for protection during external development. This chapter will review the nature and regulation of the various cellular processes of fertilization, including the development of fertilization competence, gamete signaling, sperm-oocyte fusion, the oocyte to embryo transition, and production of an eggshell to protect the developing embryo.

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Die Cortisol-Aufwachreaktion bei Patienten mit akuten und chronischen Rückenschmerzen

Abstract: Behavioral paincoping-strategies should be considered as a potentially important contributing psychological factor in the relation between the activity of the hypothalamic-pituitary-adrenal axis and stress-related pain disorders.

Cited by 18 publications

References 38 publications

The Role of Stress Regulation on Neural Plasticity in Pain Chronification

The Role of Stress Regulation on Neural Plasticity in Pain Chronification

Exploring the relationship between chronic pain and cortisol levels in subjects with osteoarthritis: results from a systematic review of the literature

Fertilization

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