Die Chemie der Blutgerinnung

Morawitz, P.

doi:10.1007/bf01955593

Cited by 11 publications

(3 citation statements)

References 49 publications

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“…TF, prothrombin, Ca 2+ ions, and fibrinogen), only TF, the initiator of blood coagulation, must be released either from blood cells or a damaged tissue, whereas the three other components are continuously present in circulation [30,31]. Much of subsequent biochemical research focused on isolation of TF from various sources.…”

Section: Tf Backgroundmentioning

confidence: 99%

Blood Coagulation and Alternative Pre-mRNA Splicing: An Overview

Bogdanov¹

2006

CMM

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Throughout the 20th century, great advances were made in understanding of how blood coagulation occurs, what physiological and biochemical mechanisms are responsible for its regulation, and what genes and their protein products comprise the essential components of the hemostatic network. Recently, complete sequencing of the human genome revealed that the structural diversity of higher eukaryotes cannot be solely attributed to the number of protein-encoding genes, whereas tools of molecular biology helped establish that pre-mRNAs produced by most protein-encoding genes undergo alternative splicing, a mechanism that enables production of multiple protein isoforms by a single gene. Research in the field of thrombosis and hemostasis revealed that the genes encoding several critical proteins at various junctures of the coagulation cascade produce alternatively spliced protein isoforms with distinct structural and biochemical characteristics, revealing a principally novel dimension in the regulation of blood clotting and, possibly, a few novel therapeutic approaches to treatment of abnormal hemostasis. This review summarizes recently published data pertaining to biosynthesis of the alternatively spliced isoforms of tissue factor (TF, or coagulation factor III), tissue factor pathway inhibitor (TFPI), and coagulation factor XI (FXI), and discusses future directions of this continuously evolving area of biomedical research, with an emphasis on molecular mechanics responsible for regulation of constitutive as well as alternative pre-mRNA splicing.

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Section: Tf Backgroundmentioning

confidence: 99%

Blood Coagulation and Alternative Pre-mRNA Splicing: An Overview

Bogdanov¹

2006

CMM

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“…The modern era of coagulation understanding was heralded in by Morawitz’s 33 1905 proposal of a “classic theory of blood coagulation” in which only four factors were involved, namely, thrombokinase (i.e., thromboplastin) from damaged tissue, prothrombin, fibrinogen, and calcium. Yet the fascination with blood clotting predated Morawitz, as far back as the ancient Greeks 31 .…”

Section: Figurementioning

confidence: 99%

A History of Coagulopathy in Liver Disease: Legends and Myths

Northup

2020

Clin. Liver Dis.

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Cirrhosis and its end-stage complications have been well-known by medical practitioners for many centuries and were frequently described in historical writings and medical literature as far back as Hippocrates in 400 bce. 1 The ancient Greeks believed the liver to be the center of the circulation and the site of blood production, perhaps because of its propensity to bleed when injured in battle or accidents. Indeed, the liver was referred to by Galen 2 as the "blood sac" because of its abundant blood flow, which comes from its almost unique dual blood supply, namely, the hepatic artery and the portal vein (almost because there is also a portal venous system between the pituitary and the hypothalamus 3) (Fig. 1). In 200 ce, Galen wrote of the liver as the fons venarum, the source of the major veins of the body and the sanguifactionis officina or the "factory of the blood," the site of sanguification. 2 In modern times, even after the gross anatomy of the liver was clearly elucidated, poor understanding of liver disease resulted in a diagnosis of cirrhosis Abbreviations: ADAMTS13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; AHG, antihemophilic globulin; aPTT, activated partial thromboplastin time; AT, antithrombin; C, protein C; FFP, fresh frozen plasma; HMWK,

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“…Αϊ μελέται των Buchanan, Denis καί Hammarsten, ή παρατήρησις των Arthus καί Pages ότι τά εκχυλίσματα ιστών επιταχύνουν τήν πήξιν τοϋ αίματος ένώ ταύτα δέν έχουν καμμίαν άπ'εύθείας έπίδρασιν έπί τοϋ ίνω δογόνου, ώς καί ή ύπόθεσις τοϋ Schmidt δτι είς τό πλάσμα τοΰ αίματος υπάρχει πρόδρομος ουσία της θρομβίνης, ήτις ώνομάσθη προθρομβίνη, ο δήγησαν τόν Morawitz (1904) Ή παράτασις τοϋ χρόνου τούτου έπί διατετηρημένου φυσιολονικοϋ πλά σματος ώδήγησεν εύς τήν άνακάλυφιν του παράγοντος V (Quick,1943Owren, 1947.…”

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Διαδοχικαι Μετρησεις Του Σχετιζομενου Με Τον Παραγοντα Viii Αντιγονου Και Η Δραστηριοτης Του Παραγοντος Της Ριστοσετινης Επι Οξεων Αρτηριακων Θρομβωτικων Επεισοδιων.

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Die Chemie der Blutgerinnung

Cited by 11 publications

References 49 publications

Blood Coagulation and Alternative Pre-mRNA Splicing: An Overview

Blood Coagulation and Alternative Pre-mRNA Splicing: An Overview

A History of Coagulopathy in Liver Disease: Legends and Myths

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