Die Blutgerinnung bei Neugeborenen und ihre St�rungen

Künzer, W

doi:10.1007/bf01494059

Cited by 26 publications

(9 citation statements)

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“…In spite of this in vitro impaired platelet function and of the lower activity of coagulation factors, term newborns have no bleeding tendency. On the contrary, the bleeding time is even shorter than in adults (24) and signs of hypercoagulability have been described in newborns (10,15). Until now, this discrepancy between the in vitro and in vivo behavior of the coagulation system has not been entirely explained.…”

Section: Discussionmentioning

confidence: 99%

“…Breast milk has only one quarter of the vitamin K contained in cow's milk formulas. Although several authors have demonstrated that the administration of vitamin K to the newborn is to some extent beneficial in raising the activity of the factors of the prothrombin complex (1, 2, 23), the significance of vitamin K deficiency during the newborn period has been questioned by others (4,10,18). This discrepancy might be explained by the wide range in variability of the prothrombin activity in normal neonates (2) and by changes in hematocrit and blood volume during the first days of life.…”

Section: ++ -mentioning

confidence: 99%

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Immunologic Studies of Prothrombin in Newborns

et al. 1979

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SummaryProthrombin of newborns was investigated by means of the quantitative immunoelectrophoresis and the two-dimensional immunoelectrophoresis. The plasma of 10 of 24 healthy term newborns and of 5 preterm infants taken immediately after birth showed one prothrombin precipitate in the a-2-fi-globulin position when a buffer containing 25 mM calcium lactate was used. No differences in the mobility and form of the precipitate could be observed as compared to healthy adults. The plasma of the other 14 term newborns and one small-for-date infant showed two precipitates, one in the a-2-&globulin position and a second in the a-1-globulin position. Twenty-four hr after the injection of vitamin K, the precipitate in a-1-globulin position was no longer evident.When a buffer without calcium was used in the two-dimensional immunoelectrophoresis, only one precipitate in the a-1-globulin position was found in all newborns. In the quantitative immunologic determination, the prothrombin was found to be decreased as compared to that of adults. The quantitative immunologic determination and the activity assay gave equal results in those infants who had only one precipitate in the two dimensional immunoelectrophoresis. In those newborns, who had two precipitates, the quantitative immunologic determination gave higher results than the measurement of the activity assay.From this study, no evidence of differences between the prothrombin of newborns and that of adults could be derived. Vitamin K deficiency, as judged from the appearance of a second peak in a-1-globulin position in the two dimensional immunoelectrophoresis was a frequent finding in term newborns, even on the 1st day of life. small for date. Five were prematures with a gestational age of 3 1-35 wk. None of these five prematures had perinatal problems, in spite of their prematurity. All but two children received 1 mg/kg vitamin K (Konakion) im shortly after birth.Immediately after birth, blood was drawn from the umbilical vein and again 24 hr afterwards by puncturing a peripheral vein. Blood samples were collected in plastic tubes containing 1/10 volume of 0.1 M trisodium citrate. The plasma was stored at -20' C until the determinations were carried out.Prothrombin activity was determined by the one stage assay (20) using a test kit of the Behring Co.Prothrombin was quantified immunologically according to Laurel] (1 I), using a monospecific rabbit antiserum against prothrombin (Behring Co): 1% agarose, barbital buffer of a pH of 8.6, 6-7 V/cm.Calibration curves for the activity and for the quantitative immunologic determination were done with a pooled plasma of 20 healthy adults and the results were expressed in percent of this pooled piasma. Two-dimensional immunoelectrophoresis (4, 5) was done, using rabbit antiserum against human prothrombin 1) with a barbital buffer of a pH of 8.6 and 2) with a barbital buffer of a pH of 8.6 and 25 mM calcium lactate. Agarose, 1%, first dimension 6-7 V/ cm for 4 hr, second dimension 2-3 V/cm for 12-14 hr.Plasma of healthy adults a...

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Section: Discussionmentioning

confidence: 99%

Section: ++ -mentioning

confidence: 99%

Immunologic Studies of Prothrombin in Newborns

et al. 1979

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“…Am häufigsten sind intrakranielle und Darmblutungen, sowie Cephalhämatome [18]. Bei einer allgemeinen Normo-bzw.…”

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“…Bei einer allgemeinen Normo-bzw. Hyperkoagulämie [1, 17,26] sind in den ersten Lebenstagen die Einzelgerinnungsfak toren herabgesetzt [17], In letzter Zeit kamen auch erste ausführlichere 1 Herrn Prof. Dr. J. Ströder Berichte über vorübergehende quantitative und qualitative Thrombozy tenveränderungen bei Neugeborenen in den ersten Lebenstagen [15,20,21].…”

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“…Die intrauterine oder perinatale Asphyxie führt zum perinatalen Schock. Blut druckabfall bewirkt über Katecholaminausschüttung Vasokonstriktion der Arteriolen, Hypoxie, Acidose und zuletzt Gewebs-und Blutzellschä digung [18]. Es ist noch nicht bekannt, wie diese Vorgänge auf die Thrombozyten einwirken und ob sie vielleicht eine Freisetzungsreaktion (release reaction) mit viskoser Metamorphose verursachen können.…”

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Die spontane, standardisierte Thrombozytenadhäsion und -aggregation in der Zählkammer

Podolsak¹

1973

Acta Haematol

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An easy, economic and standardised method of orientation about the 3 most important platelet functions, out of a small quantity of blood is described. In order to examine the reliability of this method a comparative study between the aggregation results in the counting chamber and the platelet aggregation test (PAT) according to BreddIN was carried out. To obtain an exact determination of aggregation in the counting chamber not only the classification into aggregation grades (visual criterium) was taken but also after counting the ‘free platelets’ the aggregation index (PAgI) according to Reuter et al. was calculated. The good concordance of the comparative results of these 2 technically totally different methods are discussed.

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Zur Entstehung pulmonaler hyaliner Membranen: Akute disseminierte intravasale Gerinnung und konditionierende Faktoren

Esch¹,

Cremer²

1975

Anaesthesiology and Resuscitation / Anaesthesiologie Und Wiederbelebung / Anesthésiologie Et Réanimation

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Die Blutgerinnung bei Neugeborenen und ihre St�rungen

Cited by 26 publications

References 21 publications

Immunologic Studies of Prothrombin in Newborns

Immunologic Studies of Prothrombin in Newborns

Die spontane, standardisierte Thrombozytenadhäsion und -aggregation in der Zählkammer

Zur Entstehung pulmonaler hyaliner Membranen: Akute disseminierte intravasale Gerinnung und konditionierende Faktoren

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