Die Bildung von Syndromen im AMP-System

Gebhardt, R.; Pietzcker, A.; Freudenthal, K; Langer, C.

doi:10.1007/bf00342833

Cited by 26 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The AMP syndrome scores for the paranoid-hallucinatory syndrome (St> were caleulated for eaeh patient and interview aeeording to Gebhardt et al (1981). "Response" to treatment was defined as a reduction of St on day 14 of at least 50 %, the patients thus being divided into "Responders" and "Nonresponders".…”

Section: Methodsmentioning

confidence: 99%

Can Changes in Eye-Contacts Predict Therapeutic Outcome in Schizophrenic Patients Undergoing Neuroleptic Treatment?

Meya¹,

Renfordt²

1986

Pharmacopsychiatry

View full text Add to dashboard Cite

The proportion of interview time spent in eye-contacts was studied before the onset of and during neuroleptic treatment in a group of 24 male schizophrenic patients. A significant increase in eye-contacts after 14 days distinguished responders to neuroleptic treatment, while a tendency towards the same effect distinguished patients treated with haloperidol from those treated with perazine. Only in the subgroup of responders was there a significant relationship between increase in eye-contacts and reduction of psychopathologic symptoms, regardless of whether these values were compared for the same treatment days or whether early changes in eye-contacts were compared with final outcome of treatment after 28 days. Since the patient subgroups were rather small, the results should still be considered preliminary. A prospective study including more parameters of visual interaction, a larger patient sample, and a longer observation period is required.

show abstract

Section: Methodsmentioning

confidence: 99%

Can Changes in Eye-Contacts Predict Therapeutic Outcome in Schizophrenic Patients Undergoing Neuroleptic Treatment?

Meya¹,

Renfordt²

1986

Pharmacopsychiatry

View full text Add to dashboard Cite

show abstract

“…Die Schätzwerte der Minus-wurden von denen der Plussymptomatik subtrahiert; der Differenzbetrag vertrat als "Prozeßakuität" die aktuelle (+ )/(-) Dominanz der Plusüber die Minussymptomatik. Für das Kollektiv Ir (n -208) wurden die symptomadditiven Gebhardtschen Primärskalen zum AMP-System benutzt (Gebhardt et al 1981, Baumann et al 1983. Die Plussymptomatik umfaßte die Skalen 1/"Paranoid-halluzinatorisches Syndrom" (S) (15 Details), 6/"Hostilitäts-Syndrom" (6 Details), 7/"Stuporöses Syndrom" (6 Details) und 9/"Zwangssyndrom" (3 Details).…”

Section: Zur Psychometrieunclassified

Pathophysiologische Regelmechanismen bei chronisch Schizophrenen

Klempel¹

1991

Fortschr Neurol Psychiatr

View full text Add to dashboard Cite

Two collectives of chronic schizophrenics were psychometrically rated by means of the BPRS and of Gebhardt's primary AMP-scales. Their scores of coexistent Positive and Negative Symptomatology were correlated with equivalents of catecholergic levels of tone as represented by plasma tyrosine concentration in its role as the catecholergic precursor. Levels of catecholergic tone state- and time-dependently correlated directly with Positive and inversely with Negative Symptomatology. Opposite ends of catecholergic tone from supra- to subnormal ranges ran parallel to a psychometric continuum from predominant Positive to predominant Negative Symptomatology, to a diagnostic continuum from "paranoid" to "disorganised/hebephrenic", and to a global metabolic continuum from under- to overweight. Findings did not support the hypothesis on psychotogenic dopaminergic supersensitivity. Postulated was a primary psychotogenic process of denervation or/and degeneration of a specific 'trigger system', and supersensitivity-induced neuronal damage was conjectured the biological substrate of Negative Symptomatology. A pathophysiological hypothesis put forth, corresponded with Cannon's Rules within the frame of functional neuronal plasticity.

show abstract

“…A number of factor analyses have been carried out with the AMDP items (cf. Sulz- Gebhardt et al 1981), in order to identify the underlying syndrome structure. Existing factor analyses show good agreement (Pietzcker et al 1982).…”

Section: Instruments 0/ Measurementmentioning

confidence: 99%

Prediction and Evaluation Criteria in Perazine Therapy of Acute Schizophrenics: Psychopathological Results*

Hw¹,

Rein²,

Straube³

et al. 1983

Pharmacopsychiatry

View full text Add to dashboard Cite

In a pharmacopsychiatric pilot study 28 patients with an acute schizophrenic illness were treated for 4 weeks with perazine (Taxilan). Research goals in the psychopathological investigation were: (1) to assess the range of efficacy, target symptoms and syndromes of perazine and to compare these results with previous studies; (2) to compare the quality, interrater reliability, and practicability of two instruments of psychopathological assessment (AMDP and BPRS) for measuring change during treatment; (3) to apply new mathematical methods for finding statistically significant changes in symptomatology on the item level as well as on the levels of syndrome and total score; (4) to test whether pre-treatment prediction based on psychopathological evaluation or psychophysiological data is possible. The target symptoms and syndromes of perazine were the "positive" schizophrenic syndromes, above all thought disturbances and delusional phenomena. This result was consistent with a former perazine investigation. The BPRS proved to be a practicable and reliable instrument for a more global evaluation of change in psychopathology. The AMDP seemed to be especially useful for evaluating the homogeneity of a sample and showing differentiated psychopathological profiles. On this scale, changes in symptomatology became statistically apparent more clearly and more quickly on the syndrome level rather than on the level of single items. As to interrater reliability, both scales perform well. Dichotomizing the original scaling may mean a loss of information from both scales (AMDP and BPRS) in their evaluation of change. Hence it seems necessary to introduce new mathematical procedures (e.g., Friedman and Dunn-Rankin tests) into pharmacopsychiatric research.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Die Bildung von Syndromen im AMP-System

Cited by 26 publications

References 5 publications

Can Changes in Eye-Contacts Predict Therapeutic Outcome in Schizophrenic Patients Undergoing Neuroleptic Treatment?

Can Changes in Eye-Contacts Predict Therapeutic Outcome in Schizophrenic Patients Undergoing Neuroleptic Treatment?

Pathophysiologische Regelmechanismen bei chronisch Schizophrenen

Prediction and Evaluation Criteria in Perazine Therapy of Acute Schizophrenics: Psychopathological Results*

Contact Info

Product

Resources

About