Die Beurteilung der Kontraktilität mittels enddiastolischem Volumen und Druckanstiegsgeschwindigkeit (dp/dt) beim Hund

Force-velocity Relationship of the Left Ventricle in the Closed-chest Dog

“…Consequentely, there is no evidence of changes in contractility. The finding that the infusion of angiotensin II does not lead to a depressed myocardial function, as is suggested during the ejection phase, is somewhat in contrast to another finding from this laboratory (15). It was discovered that under a similar pressure load the maximal rise of left ven tricular pressure (max.…”

“…From the inverse behaviour of max. dp/dt and EDVI under angiotensin it was concluded that the myocardial function was somewhat depressed (15). The discrepancy of this finding with that from the force-velocity diagram might be partially ex plained by the fact that the former deals with the isovolumetric part of the contraction whereas the latter is concerned with the ejection phase.…”

“…Since these values were taken from various experimental studies previously reported (7,8,15) the anesthesia was different: In 14 dogs chloralose was given intravenously in a dose of 95mg/kg (12). Force-velocity relationship of cat papillary muscle.…”