Die beruflichen Hautkrankheiten

Chemical Hypersensitivity and Dermatological Diseases

“…As th e patien ts in every group are from the same m aterial, hardly differing from one another as regards age, sex, hom e and occupation [3,5,15,19,24,27,37,39,40,44,46,47,48,49,50], the differences of hypersensitivity of th e several groups cannot be explained by exter nal factors. Therefore, we m ay suppose th a t the skin diseases and the in ten sity (frequency) of hypersensitivity have some correlation.…”

“…Therefore, in ju ry or lack of epiderm is alone does not necessarily result in chem ical hypersensitivity, th u s other factors m u st tak e p a rt in it as well [4,5,9,15,16,18,21,22,29,34,36,39,40,41,42,43,45].…”

“…The fact th a t significantly greater sensitivity can be found m erely in acute allergic skin diseases is to be explained only w ith epiderm al injuries. The conditions of the horny layer pre sum ably is a very im p o rtan t factor: the penetration of the chemicals and th eir turn in g to an allergen is rendered easy through the denuded and/or functionally dam aged skin (Tables I and II , [1][2][3][4][5] and so sen sitiv ity m ay occur even when it cannot happen in cases of in ta c t epi derm is [6,7,10,13,14,16,17,22,33,38,42,43].…”

“…From the view point of occupational health the increasing hyper sensitivity to chemicals is of great im portance [5,11,15,20,23,28,30,31,34,35,40,49]. B u t despite large scale exam inations the con ditions and circum stances of the developm ent of hypersensitivity to chemicals are still insufficiently understood in m any respects.…”