Die Bedeutung des Ultraschalls bei Mikrolithiasis des Hodens von andrologischen Patienten

Schrey, A; Wj, Reiter; Kratzik, Christian

doi:10.1055/s-2001-15240

Ultraschall in Med

2001

DOI: 10.1055/s-2001-15240

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Die Bedeutung des Ultraschalls bei Mikrolithiasis des Hodens von andrologischen Patienten

A Schrey¹,

Reiter Wj²,

Christian Kratzik³

Abstract: TM is a rare condition even in andrological patients. Nevertheless, a thorough scrotal sonography is mandatory in order to rule out testicular malignancy.

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Cited by 3 publications

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Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults

Tan

Ang

Ching

et al. 2010

Cancer

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BACKGROUND:There is an increasing body of literature associating testicular microlithiasis (TM), a common finding on testicular ultrasound, with testicular germ cell tumor (TGCT) and intratubular germ cell neoplasia of unclassified type (ITGCNU). Determining these associations is pertinent both clinically and biologically. To the authors' knowledge, no previous systematic review or meta-analysis has been performed. METHODS: A comprehensive systematic literature review was performed without language restrictions through July 2009 and included an exhaustive search of electronic databases and article references. Two reviewers extracted data independently. Studies were categorized according to the clinical context in which sonography was performed. The primary study outcomes were concurrent diagnoses of TGCT or ITGCNU, with TM. In addition, studies with prospective follow-up of patients with TM were reviewed. RESULTS: Thirty-three studies met inclusion criteria. TM was not associated with an increased risk of TGCT in asymptomatic men. However, in referral populations, TM was associated overall with a risk ratio of 8.5 (95% confidence interval [CI], 4.5-16.1; P < .001) for a concurrent diagnosis of TGCT and 10.5 (95% CI, 5.3-20.8; P < .0001) for ITGCNU. Seventeen observational studies were identified in which the interval development of TGCT in patients with TM was reported; however, the majority of those studies did not report the follow-up of a control arm and could not be summarized. CONCLUSIONS: In the presence of risk factors, TM was associated with a substantially elevated risk of a concurrent diagnosis of TGCT and ITGCNU. The authors suggest modifications to recently proposed guidelines for the management of TM. Cancer 2010;116:4520-32.

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Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults

Tan

Ang

Ching

et al. 2010

Cancer

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Testicular microlithiasis: recent advances in understanding and management

Tan

Eng

2011

Nat Rev Urol

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Testicular microlithiasis is an infrequent but well recognized condition, which is usually incidentally identified on testicular ultrasound scan. Interest in testicular microlithiasis has increased over the past few years, owing to an observed association with testicular germ cell tumor (TGCT) and intratubular germ cell neoplasia of unclassified type (ITGCNU). This association has added to evidence that testicular microlithiasis is a feature of the testicular dysgenesis syndrome (TDS), which is postulated to underpin disorders of male reproduction such as subfertility, testicular atrophy, cryptorchidism, TGCT and other abnormalities of sexual development. Although the genetic and environmental components of TDS remain unclear, studies of the molecular basis of TGCT support a genetic component for testicular microlithiasis and have identified multiple genes that are associated with TGCT. These advances in the biological understanding of testicular microlithiasis and TGCT have not, however, resolved key clinical dilemmas in the management of patients with these diseases. The role of testicular microlithiasis in the clinical consideration of testicular biopsy is discussed in the context of the apparently healthy individual, the individual with TGCT and the individual with TDS.

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Bilateral Testicular Microlithiasis Predicts the Presence of the Precursor of Testicular Germ Cell Tumors in Subfertile Men

Brazao¹,

Pierik²,

Oosterhuis³

et al. 2004

Journal of Urology

110

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Die Bedeutung des Ultraschalls bei Mikrolithiasis des Hodens von andrologischen Patienten

Abstract: TM is a rare condition even in andrological patients. Nevertheless, a thorough scrotal sonography is mandatory in order to rule out testicular malignancy.

Cited by 3 publications

References 6 publications

Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults

Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults

Testicular microlithiasis: recent advances in understanding and management

Bilateral Testicular Microlithiasis Predicts the Presence of the Precursor of Testicular Germ Cell Tumors in Subfertile Men

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