Die Ausschaltung der exokrinen Funktion des Pankreas als Behandlungskonzept der chronischen Pankreatitis

Hoffmann, Eike; Usmiani, J; Gebhardt, Ch.

doi:10.1055/s-0028-1104898

Cited by 17 publications

(10 citation statements)

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“…Deshalb wurde -in Analogie zu den Unterbindungsversuchen von Banting und Best (1922) -schon mehrfach versucht, durch die Ligatur des Ductus pancreaticus major das ))Ausbrennen~ der chronischen Pankreatitis zu beschleunigen (Martin u. Canesco, 1947;Cannon, 1955;Madding u. Kennedy, 1973;Madding et al, 1976;Hoffmann et al, 1977).…”

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Pankreasgang-Okklusion durch Injektion einer schnellh�rtenden Aminos�urenl�sung

Gebhardt¹,

Stolte²

1978

Langenbecks Arch Chiv

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The effect of the occlusion of the pancreatic duct system with a new alcoholic solution of amino acids has been studied in animal experiments. The solution becomes solid in the duct system, is microbiologically indifferent and becomes disintegrated within 11 days. This time, however, is sufficient to keep a high-grade atrophy of the exocrine parenchyma. With this method one doesn't risk the provocation of an acute pancreatitis. The development of fistulas following exploratory excision is prevented by the filling of the duct system. The solution could be qualified for a therapeutical acceleration of the "burning-out" of the chronic pancreatitis.

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Pankreasgang-Okklusion durch Injektion einer schnellh�rtenden Aminos�urenl�sung

Gebhardt¹,

Stolte²

1978

Langenbecks Arch Chiv

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“…Mitteilungen fiber die endokrine Funktion nach Gangligatur am Menschen sind sp/irlich [8,21,27,33]. Little und Mitarbeiter fanden bei 6 Patienten keine Veranderung der Glucosetoleranz im Laufe von 2-3 Jahren nach Occlusion des Pankreasganges [27].…”

Section: I S K U S S I O Nunclassified

“…Little und Mitarbeiter fanden bei 6 Patienten keine Veranderung der Glucosetoleranz im Laufe von 2-3 Jahren nach Occlusion des Pankreasganges [27]. Reis und Mitarbeiter [33] untersuchten ebenfalls Patienten bis 4,5 Jahre nach Gangligatur und konnten keine Verschlechterung der B-Zellenfunktion -bei allerdings schon vor Ligatur bestehender verminderter Glucosetoleranz und Insulinsekretion -beobachten [20,21].…”

Section: I S K U S S I O Nunclassified

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Leistungsbilanz der Inselzellen nach Pankreasgangocclusion ? ein Langzeitversuch

Zühlke

Häring

Watermann

et al. 1983

Langenbecks Arch Chiv

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The transduodenal occlusion of the pancreatic duct with Prolamin (Ethibloc) was carried out in an experiment with 38 Göttinger minipigs. Occlusion of the pancreatic duct leads to selective atrophy of the excretory pancreatic parenchyma. Up until now it has not been clear whether the endocrine functional capacity of the gland stays intact in a long-term experiment or whether the islands of Langerhans are also altered by the pancreatic duct occlusion. The following tests were carried out by us to determine the endocrine status: 1. Intravenous glucose tolerance test (i.v. GTT); 2. Glucose assimilation analysis after CONARD (K-value); 3. Insulin analysis during i.v. GTT; 4. Intravenous Tolbutamid test. Twelve months after the occlusion, reduced glucose tolerance and a reduction in insulin secretion were detected in the intravenous glucose tolerance test. Glucose assimilation (K-value) was not changed significantly. Fasting blood sugar and basic insulin level remained unchanged. Only a small blood-sugar decrease was measured after selective B-cell stimulation with Tolbutamid. The fibrosclerosis produced by the occlusion of the pancreatic duct with Prolamin also seemed to attack the cells of the islands and lead to their partial destruction.

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“…This being the case, the application of additional procedures, effective in the transposition of the parotid duct, may be useful. Such procedures are known as duct ligature and were employed in the pancreas even earlier [5] than in the parotid gland [3]; they cause irreversible atrophy of the glandular paren chyma.…”

Section: Introductionmentioning

confidence: 99%

Occlusion of Stenon’s Duct by Prolamine: a Possible Treatment of Chronic Parotitis?

Schröder¹,

Chilla²,

Arglebe³

et al. 1982

ORL

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The histological and biochemical (amylase, protein) consequences of occlusion by prolamine of the parotid duct were studied in 5 rabbits. Histological examination 2 weeks after occlusion revealed an atrophy of glandular parenchyma consistent with a very strong decrease of exportable glandular protein (especially amylase). At the same time marked sialadenitis-like changes could be noted. Prior to a possible use of occlusion by prolamine of the parotid duct in human patients, long-term studies in animals are therefore indicated.

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Die Ausschaltung der exokrinen Funktion des Pankreas als Behandlungskonzept der chronischen Pankreatitis

Cited by 17 publications

References 1 publication

Pankreasgang-Okklusion durch Injektion einer schnellh�rtenden Aminos�urenl�sung

Pankreasgang-Okklusion durch Injektion einer schnellh�rtenden Aminos�urenl�sung

Leistungsbilanz der Inselzellen nach Pankreasgangocclusion ? ein Langzeitversuch

Occlusion of Stenon’s Duct by Prolamine: a Possible Treatment of Chronic Parotitis?

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