Die anwendung papierchromatographischer methoden zum toxikologischen nachweis von arzneimitteln

Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone).

“…On the other hand, the share of 4-formylaminoantipyrine accounts for up to 20%. Quantitatively less important metabolites include 4-acetylmethylaminoantipyrine (Vecerkova, Kakac, Vecerek & Ledvina, 1967), 4-hydroxyantipyrine (Brodie & Axelrod, 1950;Halberkann & Fretwurst, 1950;Gradnik & Fleischmann, 1973), predominantly excreted conjugated with glucuronide or sulphate, and also rubazonic and methylrubazonic acid (Jaffe, 1901;Schuppel & Soehring, 1965;Pechtold, 1964b;Preuss & Voigt, 1965). The latter occur only sporadically and it has not been finally clarified whether they are artefacts or true metabolites of aminopyrine.…”

Chromatography

“…Partition chromatography on columns was only used in two instances: the determination of barbiturates (1708) and of amphetamine (1074). New paper-chromatographic techniques have been described for various narcotics (542,893,1196,1534,1649), barbiturates (161, 315, 362, 406, 650, 833-835, 900, 1125, 1237, 1515, 1531, 1742) and other sedatives (216,392,409,421,1088,1122,1352,1529,1639,1652), analgesics (288,485,604,727,1140,1636,1642,1648,1650) antihistamines (1635,1638,1639), sulfonamides (190,650,1227,1411,1472), antiseptics (102,194), isonicotinic acid hvdrazide (84, 86), phenazine dyes (145,1277), sulfonyl ureas (255), diuretics (771), zoalene (1453), ephedrine (675) and nikethamide derivatives (289). Pesticides.…”

“…A new parameter, the isomer constant, Ra, permits the calculation of Rf values for isomers in both paper and thin-layer chromatograms (200). Correlation data for RF and Rm values have been published for a variety of compounds (463,709), including various phenols (106, 578-580,623, 994-996, 1321, 1464), monohaloanthraquinones (389), acridine derivatives (1678), and quaternary bases (124,1637). The relation between the composition of multicomponent solvent systems and R values have been evaluated (1463,1466) and some useful generalizations about solvent composition have been derived (243,1465,1584,1706).…”

Oxidative Degradation of Pharmaceutically Important Phenothiazines I: Isolation and Identification of Oxidation Products of Promethazine

“…Details were given about the identity of the products obtained, but the purity of the isolated fractions was unknown. Moreover, many reports (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) described the separation of different phenothiazines, also by TLC, paper chromatography, and GLC. These data were used for the development of a method to separate promethazine and its degradation products.…”