Die allergisch-hyperergische Entzündung

Allergic Inflammation

“…In the earliest studies carried out on the Arthus phenomenon (3) an alteration of collagen fibrils (VerqueUung) was observed. Subsequently, similar changes were often described, mostly under the term "fibrinoid degeneration," though some have denied that such alterations occur (8,9). The discrepancy is obvious in the two early attempts to study by electron microscopy the collagen fibrils in Arthus lesions.…”

“…While many (8) have accepted the view of Rich and Follis (5) that the primary site of damage in the "sensitized" animal was the endothelium, recent studies (10, 1, 2) support Opie's view (4) that the primary change is a humoral one; i.e., an interaction between the injected antigen and circulating antibody. This interaction takes place primarily in the lumen and wall of vennies and initiates the vascular reaction which seems to be responsible for the progression of the lesion (11).…”

Histological Manifestations of Cellular (delayed) Hypersensitivity

“…26, No. 3 (1965) 12 176 Kolin/Johanovsky/Pekarek hyperaemia and more difficult oxygen diffusion or due to the proteo lytic action of emigrated neutrophils (5,17). The period of 90 min from the onset of the reaction docs not suffice -according to data in the literature (2, 9, 13) and our own experience (20,21) -for the development of morphologically detectable hypoxic necrosis, not even in metabolically much more active cardiac muscle fibres which are more sensitive to oxygen lack.…”

Granulomatous Lesions in Ileocolitis

“…Investigators in the field of fundamental pathology such as Ehricli [15J, Lelterer [16], and Forhus [17] consider that tin's type of tissue reaction is frequently encountered in the delayed allergic response also called t he tuberculin type of reaction. This is suggested by ) am is and Crohn when they sax that ulceration or granuloma as a basic form of reac tion may depend on " different reactivitynot on different etiology.…”