Didemnacerides A and B: two new glycerides from Red Sea ascidian <i>Didemnum</i> species

Ibrahim, Sabrin R. M.; Mohamed, Gamal A.; Shaala, Lamiaa A.; Youssef, Diaa T. A.; Gab-Alla, Ali

doi:10.1080/14786419.2014.927874

Cited by 7 publications

(5 citation statements)

References 36 publications

(39 reference statements)

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“…The 22 new tunicate-derived natural products presented in this review is the second lowest number reported in one year over the last decade. A structurally-diverse range of metabolites were reported, with examples of glycerides 1314 and 1315, 832 amino alcohols 1316-1322, 833 new didemnaketal congeners 1323, 1324 834 and 1325, 1326, 835 halogenated alkaloids 1327 and 1328, 836 a new rubrolide (R) 1329 837 (that unfortunately shares the same letter designation as a related metabolite reported from Aspergillus terreus 217 ), pyridoacridine cnemidine A 1330 552 and sulfated sterols 1331 and 1332. 838 Noteworthy was the isolation, structure elucidation and synthesis of a rare example of a modied nucleoside bearing a 5 0 -thiomethyl substituent 1333.…”

Section: Molluscsmentioning

confidence: 99%

Marine natural products

et al. 2016

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This review covers the literature published in 2014 for marine natural products (MNPs), with 1116 citations (753 for the period January to December 2014) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1378 in 456 papers for 2014), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Molluscsmentioning

confidence: 99%

Marine natural products

et al. 2016

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“…Soft corals were classified as; Heteroxenia fuscescens, didemnum moseleyi, Lobophytum pauciflorum, Sarcophyton trocheliophorum and Sinularia spp. which was reported by Ibrahim et al (2014), Afifi et al (2016), Hassan et al (2016), Tarek et al (2016) and Zubair et al (2016), . Sponges were classified to: Ircinia strobilina, Callyspongia viridis, Suberea spp, Spongia officinalis and Biemna ehrenbergi, this was reported by Ilan et al (2004), El-Ganainy et al (2005, Mohamed et al (2014) and Almohammadi (2017) (2014) .…”

Section: Discussionmentioning

confidence: 61%

Bacterial diversity and distribution in Soft Corals and Sponges in the Red Sea

Sallam¹,

Hriri²,

Mahmoud³

et al. 2019

Egypt. J. of Aquatic Biolo. and Fish.

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The Red Sea has high biodiversity, with at least 266 coral and sponge species. The coral/Sponge holobiont is comprised of the coral/sponge animal and its associated microorganisms consisting of bacteria, archaea, fungi and viruses. It has been hypothesized that this interaction plays a role in coral/ sponge defense. This study aims to study the biodiversity of some collected types of sponge and soft coral from Red Sea and to isolate associated bacteria from them. The result includes five types of sponges; Ircinia strobilina, Callyspongia viridis, Suberea spp., Spongia officinalis and Biemna ehrenbergi and five types of soft corals; Heteroxenia fuscescens, Didemnum moseleyi, Lobophytum pauciflorum, Sarcophyton trocheliophorum and Sinularia spp. Twenty two bacterial isolates were isolated from the sponges with 41 % and thirty two bacterial isolates were isolated from soft coral samples with 59 % collected from different Red Sea areas.

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“…The known metabolites M0 and M1 are identified as PD (R) and PD (S), respectively. M2, 3β,21α,22β-hydroxy-24-norolean-12-ene; M3, 5α,8α-dihydroxycholest-6-en-3β-ol; M4, (3β,12β,24S)-20,24-epoxydammar-25-ene-3,12-diol; M5, (3β,4β,22β)-olean-12-ene-3,22,23-triol; M6, soyasapogenol E. The NMR spectra are in good agreement with those reported. ,− …”

Section: Resultsmentioning

confidence: 73%

In Vivo Metabolites of Panaxadiol Inhibit HepG-2 Cell Proliferation by Inducing G1 Arrest and ROS-Mediated Apoptosis

Xiao

Lee

et al. 2022

J. Agric. Food Chem.

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In this study, 10 metabolites were obtained by collecting and extracting fecal samples after oral administration of panaxadiol (PD). Of these 10 metabolites, M7 (3β,21β,22α-hydroxy-24-norolean-12-ene), M8 (21β,22α-hydroxy-24-norolean-12-ene-3-one), M9 (3β,30α-hydroxy-24-norolean-22,30-epoxy-12-ene), and M10 (3β,21β-hydroxy-24-norolean-12-ene) were new compounds. MTT screening of the isolated compounds revealed that the inhibitions of cancer cells by M2, M4, M7, M8, and M10 were significantly stronger than that by the mother drug M0, with the activity of M2 being the most significant. Further, we investigated the anticancer mechanism of M2. The results showed that M2 significantly increased the level of ROS in cells; regulated the expressions of Bax, Bcl-2, and Cyt-C through the mitochondrial pathway; triggered the caspase cascade; and induced apoptosis. M2 could also induce G1 phase arrest and significantly regulate cell cycle-related proteins. In conclusion, the experimental results provide data for further study on the metabolic mechanism of PD in vivo and the potential of developing new anti-cancer drugs.

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Didemnacerides A and B: two new glycerides from Red Sea ascidian Didemnum species

Cited by 7 publications

References 36 publications

Marine natural products

Marine natural products

Bacterial diversity and distribution in Soft Corals and Sponges in the Red Sea

In Vivo Metabolites of Panaxadiol Inhibit HepG-2 Cell Proliferation by Inducing G1 Arrest and ROS-Mediated Apoptosis

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