This review article examines the National Institutes of Health's (NIH) overall budget and its pediatric research funding across three time periods: predoubling [fiscal year (FY) 1992(FY) -1997; doubling (FY 1998(FY -2003; and postdoubling (FY 2004(FY -2009). The average annual NIH appropriations increased by 5.4%, 13.4%, and 1.3% in each period, respectively. The average annual pediatric research funding (actual grants, contracts, intramural research, and other mechanisms of support) increased much less, by 4.7%, 11.5%, and 0.3% in each period, respectively. Between FY 2004 and FY 2007, the average NIH budget increase has nearly flattened, to only 1.96%. During this period, average pediatric research funding has dropped markedly lower, to 0.57%; estimated FY 2008 pediatric funding is at negative 0.5%. Although pediatric research enjoyed significant benefits of the NIH doubling era, the proportion of the NIH budget devoted to the pediatric research portfolio has declined overall. The most recent period has wiped out the annual gains of the doubling era for both pediatric and overall NIH research funding. We offer recommendations to protect against further erosion of pediatric research funding and to implement several unfulfilled commitments to strengthen the federal pediatric research portfolio in the coming decade. T he allocation of US federal budget outlays to the needs of children is a major area of interest for policymakers, child advocacy groups, clinical pediatricians, and academic pediatric researchers. Until recently, no comprehensive estimates of federal expenditures on children were available.1 In an important March 2007 study, the Urban Institute reported on trends in federal funding on children from 1960 to 2017 of more than 100 major federal programs, including the federal income tax.2 The study noted that in 1960, children's share of domestic federal spending was roughly 20% (or $53 billion of $263 billion). By 2006, its share of the total was little more than 15%. Thus, as a percent of federal domestic spending, children's spending declined during this period. In 2006, children represented 26% of the population (1). By 2017, current projections indicate that children's share of domestic federal spending will drop to about 13% (2). This analysis concludes that children are a "diminishing" national priority.Prior scholarly efforts to analyze funding on children at National Institutes of Health (NIH) focused only on the flow of dollars to academic pediatric departments rather than on overall pediatric research funding as an independent category (3-5). With a specific interest in the status of the federal pediatric research portfolio, Gitterman et al. (2004) reported on trends in pediatric research funding in absolute terms and relative to the NIH budget, with a specific focus on the doubling period [fiscal year (FY) 1998 -2003] when congressional appropriations increased from $13.6 billion to $27.1 billion. The intent in this report was to avoid interpreting funding as a competition b...