Diclofenac Suppository as a Preemptive Analgesia in Ultrasound-guided Biopsy of Prostate: Randomized Controlled Trial

Haroon, Naveed; Ather, M Hammad; Khan, Salma; Kumar, Pirkash; Salam, Basit

doi:10.1016/j.urology.2015.04.044

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…Previous studies demonstrated the efficacy of preoperative oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) inhibitors, 1 gabapentin and pregabalin, 3,14 and other drugs. Preemptive intravenous administration of ketorolac, 25 ketamine, 49 propofol or remifentanil, 26 as well as suppository of diclofenac 29 also reduced postoperative pain intensity. The latest nonconventional methods of preemptive analgesia are frequency rhythmic electrical modulation system, 2 electroacupuncture, 60 and transcutaneous electrical nerve stimulation (TENS).…”

Section: Discussionmentioning

confidence: 97%

Preemptive Local Anesthesia in Ankle Arthroscopy

Liszka

Gądek

2016

Foot Ankle Int.

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Section: Discussionmentioning

confidence: 97%

Preemptive Local Anesthesia in Ankle Arthroscopy

Liszka

Gądek

2016

Foot Ankle Int.

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“…The PGE2 enhances the pain receptor’s sensitivity to algesic substances such as bradykinin and substance P 29. Centrally, prostaglandins act in the spinal cord and higher centers to promote the transmission of pain signals to the brain 30. A study by Silva et al,31 was carried out to investigate the effectiveness of ibuprofen and etodolac for controlling pain, swelling, and trismus following surgical removal of the lower third molars.…”

Section: Discussionmentioning

confidence: 99%

Comparison of paracetamol, ibuprofen, and diclofenac potassium for pain relief following dental extractions and deep cavity preparations

Gazal¹,

Al-Samadani²

2017

SMJ

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Objectives:To compare the effectiveness of different oral analgesics for relieving pain and distress in adults following the extraction of teeth and deep cavity preparations under local anesthesia.Methods:This randomized controlled study was conducted between November 2015 and May 2016. One hundred and twenty patients were randomly allocated to 3 groups. Forty patients were in the paracetamol (1 gram) group, 40 in the ibuprofen (400 mg) group and 40 in the diclofenac potassium (50 mg) group. Evaluation of the post extraction and deep cavity preparations pain was made by patients immediately postoperatively, 2, 4 and 6 hours postoperatively on standard 100 mm visual analogue scales (VAS). Furthermore, each patient was observed preoperatively and immediately postoperatively for signs of distress by using a 5 point face scale.Results:There were significant decreases in mean pain VAS scores for diclofenac potassium group compared to paracetamol and ibuprofen groups at 4 hours postoperatively (one-way Analysis of Variance: p=0.0001, p=0.001) and 6 hours postoperatively (p=0.04, p=0.005). Changes in distress scores from the preoperative score to the postoperative score were made using the paired sample t-test. There were significant decreases in distress scores between the preoperative and postoperative scores (p=0.0001).Conclusions:Diclofenac potassium was more effective than paracetamol or ibuprofen for reducing postoperative pain associated with tooth extraction and deep cavity preparation. Patients’ distress levels can be alleviated by using preemptive analgesics.

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“…Intensive repeat biopsy protocols aimed at maximizing cancer detection; however, can potentially lead to longer and more painful procedures [2]. Discomfort and pain during TRUS-PBx received little attention until recently [3].…”

Section: Introductionmentioning

confidence: 99%

A Novel Pain Alternative for Patients with Anorectal Pathologies: The Comparison of Transperineal Prostatic Blockage Technique with Periprostatic Nerve Blockage and Rectal Gel Technique in Initial Transrectal Ultrasound-Guided Prostate Biopsy - A Prospective, Randomized Trial

Bolat¹,

Değirmenci²,

Günlüsoy³

et al. 2016

Urol Int

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Introduction: The study aimed to compare the efficiency of periprostatic nerve blockage (PPNB) and intrarectal lidocaine gel (PPNB + gel) with a transperineal prostatic block (TPPB) technique during transrectal ultrasound-guided prostate biopsy (TRUS-PBx) in patients with anorectal pathologies. Materials and Methods: A total of 376 patients who underwent TRUS-PBx were randomized into 2 groups. Group-I (n = 198) received TPPB with 10 ml 2% prilocaine, and group-II (n = 178) received intrarectal administration of 10 ml 2% lidocaine gel followed by PPNB with 10 ml 2% prilocaine. A 10-point linear visual analogue scale (VAS) was used to assess the pain arising from probe insertion (VAS-1) and prostate sampling (VAS-2). Results: VAS-1 scores were significantly lower in group-I than group-II (1.7 ± 1.9 vs. 3.9 ± 1.5; p < 0.001). Combining local anesthesia produced superior pain control to TPPB during sampling (2.0 ± 1.2 vs. 2.5 ± 2.4; p = 0.015). Following subgroup analyses with reference to concomitant anorectal pathologies, VAS-1 scores were significantly lower in group-I than group-II (2.0 ± 1.8 vs. 5.5 ± 1.7; p < 0.001). VAS-2 scores were lower in group-II than group-I; however, the difference was not considered significant (2.4 ± 1.3 vs. 3.1 ± 2.8; p = 0.303). Conclusions: In all patients referred for TRUS-PBx, TPPB is a good alternative to PPNB + gel. TPPB can be particularly useful for patients with anorectal pathologies due to its improved pain reduction during probe insertion.

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Diclofenac Suppository as a Preemptive Analgesia in Ultrasound-guided Biopsy of Prostate: Randomized Controlled Trial

Cited by 9 publications

References 8 publications

Preemptive Local Anesthesia in Ankle Arthroscopy

Preemptive Local Anesthesia in Ankle Arthroscopy

Comparison of paracetamol, ibuprofen, and diclofenac potassium for pain relief following dental extractions and deep cavity preparations

A Novel Pain Alternative for Patients with Anorectal Pathologies: The Comparison of Transperineal Prostatic Blockage Technique with Periprostatic Nerve Blockage and Rectal Gel Technique in Initial Transrectal Ultrasound-Guided Prostate Biopsy - A Prospective, Randomized Trial

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