Diclofenac reduces the incidence of acute pancreatitis after endoscopic retrograde cholangiopancreatography

Murray, Bill; Carter, Ross; Imrie, C. W.; Evans, Susan; Ó'Súilleabháin, Críostóir

doi:10.1016/s0016-5085(03)00384-6

Cited by 250 publications

(205 citation statements)

References 30 publications

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“…4 Table 4. Many anticancer drugs derived from plants were useful clinically include vinblastine irinotecan, topotecan and paclitaxel [31,32] . Several biological processes and biological interactions occur between flavonoids, phenolic compounds or polyphenols, with enzymes, proteins that make them toxic to the cell or inhibit the growth of cells [33] .…”

Section: +mentioning

confidence: 99%

In vitro Antioxidant and Cytotoxic Effects of Methanol Extracts of Vitex negundo, Lantana camara, Bauhinia variegata and Barringtonia racemosa on Human Cancer Cell lines

Badgujar¹,

Mistry²,

Chudasama³

et al. 2017

pharmaceutical-sciences

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In current study, the phytochemical, antioxidant and cytotoxic effects of methanol extracts of Vitex negundo, Lantana camara, Bauhinia variegata and Bauhinia racemosa were reported. Methanol extract of medicinal plants (V. negundo, L. camara, B. variegata and B. racemosa) were extracted using different extraction methods and then tested for their antioxidant activity by 2,2-diphenylpicrylhydrazyl, superoxide scavenging method, chelation of metal ions and cytotoxic potency using MTT assay on human cancer cell lines. In different extraction methods, highest yield was obtained with hot extraction method. Total phenolic and flavonoid contents were found higher in methanol extract of V. negundo having 173.3±1.54 mg gallic acid equivalent/g DW and 24.41±1.5 mg quercetin equivalent/g DW contents, respectively. Leaves of V. negundo have maximum IC 50 value of 73±2.76 µg/ml and 350±1.23 µg/ml in 2,2-diphenylpicrylhydrazyl and iron chelating activity compared to all other methanol extracts. B. racemosa leaves have higher superoxide scavenging effect with IC 50 value of 223±1.23 µg/ml. V. negundo and L. camara leaves showed pronounced cytotoxic effect against HELA and KB human cancer cell lines with LD 50 value of 222±3.35 and 188.69±1.4 µg/ml, respectively. The present study shows that V. negundo and L. camara may be a probable source of natural antioxidant and as an anticancer drugs.

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Section: +mentioning

confidence: 99%

In vitro Antioxidant and Cytotoxic Effects of Methanol Extracts of Vitex negundo, Lantana camara, Bauhinia variegata and Barringtonia racemosa on Human Cancer Cell lines

Badgujar¹,

Mistry²,

Chudasama³

et al. 2017

pharmaceutical-sciences

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“…Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP), with a reported incidence of 1%-10% in most prospective studies [1][2][3][4][5][6][7][8][9] . The generally accepted criteria for the diagnosis of post-ERCP pancreatitis were proposed in 1991 during a consensus workshop.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of intramuscular diclofenac and fluid replacement in prevention of post-ERCP pancreatitis

Senol¹,

Sarıtaş²,

Demirkan³

2009

WJG

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AIM:To assess the efficacy of intramuscular diclofenac and fluid replacement for prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. METHODS:A prospective, placebo-controlled study was conducted in 80 patients who underwent ERCP. Patients were randomized to receive parenteral diclofenac at a loading dose of 75 mg followed by the infusion of 5-10 mL/kg per hour isotonic saline over 4 h after the procedure, or the infusion of 500 mL isotonic saline as placebo. Patients were evaluated clinically, and serum amylase levels were measured 4, 8 and 24 h after the procedure. RESULTS:The two groups were matched for age, sex, underlying disease, ERCP findings, and type of treatment. The overall incidence of pancreatitis was 7.5% in the diclofenac group and 17.5% in the placebo group (12.5% in total). There were no significant differences in the incidence of pancreatitis and other variables between the two groups. In the subgroup analysis, the frequency of pancreatitis in the patients without sphincter of Oddi dysfunction (SOD) was significantly lower in the diclofenac group than in the control group (P = 0.047).CONCLUSION: Intramuscular diclofenac and fluid replacement lowered the rate of pancreatitis in patients without SOD.

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“…Pharmacological prevention of post-ERCP pancreatitis has focused on several postulated mechanisms of injury including relaxation of the sphincter of Oddi by calcium channel antagonists [11] and PDE-5 inhibitors [12], interruption of the inflammatory cascade by NSAIDs [13], and inhibition of pancreatic secretion by somatostatin [14] and octreotide [15]. Theoretically, intervention by different agents targeting multiple steps in the pathogenesis of post-ERCP pancreatitis may be more efficient than intervention by a single agent.…”

Section: Discussionmentioning

confidence: 99%

The Prevention and Management of Post-ERCP Pancreatitis

Lee¹,

Kim²

2016

Korean J Pancreas Biliary Tract

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Diclofenac reduces the incidence of acute pancreatitis after endoscopic retrograde cholangiopancreatography

Cited by 250 publications

References 30 publications

In vitro Antioxidant and Cytotoxic Effects of Methanol Extracts of Vitex negundo, Lantana camara, Bauhinia variegata and Barringtonia racemosa on Human Cancer Cell lines

In vitro Antioxidant and Cytotoxic Effects of Methanol Extracts of Vitex negundo, Lantana camara, Bauhinia variegata and Barringtonia racemosa on Human Cancer Cell lines

Efficacy of intramuscular diclofenac and fluid replacement in prevention of post-ERCP pancreatitis

The Prevention and Management of Post-ERCP Pancreatitis

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