Diclofenac Loaded Lipid Nanovesicles Prepared by Double Solvent Displacement for Skin Drug Delivery

Sala, M.; Locher, François; Bonvallet, M; Agusti, Géraldine; Elaı̈ssari, Abdelhamid; Fessi, Hatem

doi:10.1007/s11095-017-2201-8

Cited by 12 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on these results, amplitude sonication at 50 %, was selected for the synthesis of aspasomes loading therapeutic molecules and having the best physicochemical properties for a potential dermal application and further analysis. In fact, the PDI values of formulations A4 e B4 was below 0.2 and thus indicated a narrow size distribution of nanocarriers, [24,25] while the resulting average sizes were 147±12 for formulation A4‐son50 %, and 158±17 nm for formulation B4‐son50 % (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

Multidrug Idebenone/Naproxen Co‐loaded Aspasomes for Significant in vivo Anti‐inflammatory Activity

et al. 2022

View full text Add to dashboard Cite

The use of proper nanocarriers for dermal and transdermal delivery of anti-inflammatory drugs recently gained several attentions in the scientific community because they pass intact and accumulate payloads in the deepest layers of skin tissue. Ascorbyl palmitate-based vesicles (aspasomes) can be considered a promising nanocarrier for dermal and transdermal delivery due to their skin whitening properties and suitable delivery of payloads through the skin. The aim of this study was the synthesis of multidrug Idebenone/naproxen co-loaded aspasomes for the development of an effective anti-inflamma-tory nanomedicine. Aspasomes had suitable physicochemical properties and were safe in vivo if topically applied on human healthy volunteers. Idebenone/naproxen co-loaded aspasomes demonstrated an increased therapeutic efficacy of payloads compared to the commercially available Naprosyn® gel, with a rapid decrease of chemical-induced erythema on human volunteers. These promising results strongly suggested a potential application of Idebenone/naproxen multidrug aspasomes for the development of an effective skin anti-inflammatory therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Multidrug Idebenone/Naproxen Co‐loaded Aspasomes for Significant in vivo Anti‐inflammatory Activity

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Figure A illustrates the preparation scheme of the polyphenol/amphiphilic dendrimer NPs and their tested application at this study (Figure B). The composite NPs were synthesized according to the solvent displacement method, in which the amphiphilic dendritic polymer (Bolton W3000) and equimolar concentrations of curcumin and resveratrol were dissolved in acetone and injected into an aqueous buffer solution. Globular NPs were thus formed through the “Ouzo effect” in which nanodroplets are formed without surfactants .…”

Section: Resultsmentioning

confidence: 99%

Synergistic Activity of Anticancer Polyphenols Embedded in Amphiphilic Dendrimer Nanoparticles

Ben-Zichri

Meltzer

Lacham-Hartman

et al. 2022

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

Dendritic polymer nanoparticles (NPs) are promising vehicles for drug delivery. Most dendrimer polymer NPs, however, exhibit positive surface charge which make them, in many instances, cytotoxic. We constructed noncationic, amphiphilic dendrimer NPs embedding curcumin and resveratrol, natural polyphenols exhibiting anticancer properties. The curcumin/resveratrol/dendrimer NPs both effectively shielded the embedded polyphenols and facilitated their slow release and, notably, targeted cancer cells. The experimental data trace the cancer cell toxicity of the curcumin/resveratrol/dendrimer NPs to impairment of mitochondrial functions, specifically giving rise to enhanced intracellular calcium release, inhibition of cytochrome c oxidase enzyme activity, decreased mitochondrial membrane potential, and mitochondrial membrane perturbation. Importantly, synergism between the dendrimer-NP-embedded curcumin and resveratrol was observed, as more pronounced cancer cell death and mitochondrial disruption were induced by the curcumin/resveratrol/dendrimer NPs as compared to either the freely dissolved polyphenols or amphiphilic dendrimer NPs incorporating curcumin or resveratrol separately. This work suggests that amphiphilic dendrimer NPs encapsulating curcumin and resveratrol may constitute a promising anticancer therapeutic platform.

show abstract

“…High ZP was observed on the surface of the prepared bilosomal formulae, ranged between −30.6 mV and −49.5 mV, as shown in Table 1 and Figure 1(C) . This range could guarantee high physical stability for the bilosomes over the long term due to the significant repulsion between the similarly charged surfaces (Chun et al., 2017 ; Sala et al., 2017 ). A two-factor interaction model was adopted to analyze the measured ZP values.…”

Section: Resultsmentioning

confidence: 99%

Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency

et al. 2020

View full text Add to dashboard Cite

The work aimed to improve both absorption and hepatic availability of sofosbuvir. Bilosomes and galactose-anchored bilosomes were investigated as potential nanocarriers for this purpose. Sofosbuvir is a class III drug with high solubility and low permeability. Thus, the drug entrapment into lipid-based galactose-anchored carriers would enhance drug permeability and improve its liver availability. The galactosylated taurocholate was designed and synthesized based on molecular docking studies, where both galactose and taurocholate molecules were connected in a way to avoid affecting crucial interactions and avoid steric clashes with their cellular uptake receptors. The suggested nano-carriers were prepared using a thin-film hydration technique with sodium taurocholate and span 60 as stabilizers. The prepared formulae were statistically optimized using a central composite design. The optimized plain and galactosylated formulae, composed of SAA to drug ratio of 1:1 w/w and sodium taurocholate to span ratio of 10:1 w/w, have a vesicular size, zeta potential and entrapment efficiency in the range of 140–150 nm, −50 mV and 85%, respectively. The optimized formulae were lyophilized to increase their physical stability and facilitate accurate drug dosing. In vivo results showed that Sofosbuvir availability in the liver was significantly increased after oral administration of the plain and the galactosylated bilosomal formulae when compared to the oral drug solution with relative targeting efficiencies (RTIs) of 1.51 and 3.66, respectively. These findings confirmed the hypothesis of considering the galactosylated bilosomes a promising nanocarrier to efficiently target sofosbuvir to the liver.

show abstract

Diclofenac Loaded Lipid Nanovesicles Prepared by Double Solvent Displacement for Skin Drug Delivery

Abstract: Our results suggest that our diclofenac loaded lipid vesicles have significant potential as transdermal skin drug delivery system. Here, we produced cost effective lipid nanovesicles in a merely manner according to a process easily transposable to industrial scale. Graphical Abstract ᅟ.

Cited by 12 publications

References 38 publications

Multidrug Idebenone/Naproxen Co‐loaded Aspasomes for Significant in vivo Anti‐inflammatory Activity

Multidrug Idebenone/Naproxen Co‐loaded Aspasomes for Significant in vivo Anti‐inflammatory Activity

Synergistic Activity of Anticancer Polyphenols Embedded in Amphiphilic Dendrimer Nanoparticles

Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency

Contact Info

Product

Resources

About