Diclofenac-Induced Rhabdomyolysis

Interactions of Human Organic Anion Transporters and Human Organic Cation Transporters with Nonsteroidal Anti-Inflammatory Drugs

“…Although the chemical diversity yields a broad range of pharmacokinetic characteristics (Frust and Munster, 2000), they have some general properties in common. NSAIDs have been shown to induce various forms of adverse drug reactions including adverse gastrointestinal effects (Day et al, 2000), renal dysfunction and nephrotoxicity (Day et al, 2000), liver damage (Zimmerman, 1981;Wood et al, 1985;Purcell et al, 1991;Day et al, 2000), adverse neurological effects (Hoppman et al, 1991;Day et al, 2000), and rhabdomyolysis (Ross and Hoppel, 1987;Leventhal et al, 1989;Delrio et al, 1996).The secretion of numerous organic anions and cations, including endogenous metabolites, drugs, and xenobiotics, is an important physiological function of the renal proximal tubule. The process of secreting organic anions and cations through the proximal tubule cells is achieved via unidirectional transcellular transport involving the uptake of organic anions and cations into the cells from the blood across the basolateral membrane, followed by extrusion across the brush-border membrane into the proximal tubule fluid (Pritchard and Miller, 1993).…”

“…Although the chemical diversity yields a broad range of pharmacokinetic characteristics (Frust and Munster, 2000), they have some general properties in common. NSAIDs have been shown to induce various forms of adverse drug reactions including adverse gastrointestinal effects (Day et al, 2000), renal dysfunction and nephrotoxicity (Day et al, 2000), liver damage (Zimmerman, 1981;Wood et al, 1985;Purcell et al, 1991;Day et al, 2000), adverse neurological effects (Hoppman et al, 1991;Day et al, 2000), and rhabdomyolysis (Ross and Hoppel, 1987;Leventhal et al, 1989;Delrio et al, 1996).…”

Fatal Acute Diclofenac-induced Rhabdomyolysis In A Pediatric Patient

“…Drug-induced rhabdomyolysis is a serious, sometimes life-threatening and there are several case reports in the literature involving some common drugs that caused rhabdomyolysis (1,2,7,8). Antihistamines, anesthetics, and amphetamines have recently been implicated as the etiology of drug-induced rhabdomyolysis in several pediatric patients (1,2,7,8).…”

“…Antihistamines, anesthetics, and amphetamines have recently been implicated as the etiology of drug-induced rhabdomyolysis in several pediatric patients (1,2,7,8). Hanna et al reported a child who developed severe metabolic acidosis, progressive hypoxia, and rhabdomyolysis during a maintenance infusion of propofol for the treatment of refractory status epilepticus (9).…”

“…All reported cases of rhabdomyolysis complicating DCF overdose appeared in adults following intentional overingestion (1,2).…”