Diclofenac induced gastrointestinal and renal toxicity is alleviated by thymoquinone treatment

Aycan, İlker Öngüç; Elpek, Özlem; Akkaya, Bahar; Kıraç, Ebru; Tuzcu, Hazal; Kaya, Sabriye; Coşkunfırat, Nesil; Aslan, Mutay

doi:10.1016/j.fct.2018.06.038

Cited by 61 publications

(50 citation statements)

References 48 publications

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“…Diclofenac induction caused a decrease in gastric and duodenum tissue TAS levels and increase in ROS/RNS proportion. While increasing gastric and duodenum tissue TAS levels, TQ treatment did not cause a change in ROS/RNS proportion (23). In rats with acute alcohol-induced gastric mucosa damage, the effects of 10 mg/kg TQ were investigated.…”

Section: Discussionmentioning

confidence: 99%

Effects Of Thymoquinone and Citalopram On Oxidative Stress in Gastric and Duodenum Tissue in Reserpinized Rats

Kuzay¹

2019

Erciyes Med J

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Objective: Medicaments used in the therapy of GIS diseases have many detrimental impacts. Therefore, antioxidant effective molecules can help in the treatment process. This study aimed to examine the oxidant and antioxidant activity of thymoquinone (TQ) and citalopram in gastric and duodenum tissues of reserpinized rats. Materials and Methods: In the study, we split the rats in six groups of six rats each: 1) Control (C) 1; 2) Control (C) 2; 3) reserpine (R); 4) Reserpine+citalopram (R+C); 5) Reserpine+thymoquinone (R+T); 6) Reserpine+citalopram+thymoquinone (R+C+T). Reserpine (0.2 mg/kg) was intraperitoneally administered. TQ (10 mg/kg) and citalopram (10 mg/kg) were intragastrically administered 30 min before reserpine injection. The rats were treated for 14 consecutive days. At the end of the experiment, we examined total antioxidant status and total oxidant status in gastric tissue; and total nitric oxide, malondialdehyde, and glutathione levels in duodenum tissue. Results: There was a reduction on total oxidant status in gastric tissue in the R+C group in comparison with the R group (p<0.01). The decrease in total oxidant status in the R+C+T and R+T groups was more significant (p<0.01). An increase in total antioxidant status was observed in the R+C, R+T, and R+C+T groups when compared to the R group (p<0.01). In comparison to the R group, there was a reduction in malondialdehyde and nitric oxide levels and a rise in glutathione level in duodenum tissue in the R+C+T and R+T groups (p<0.01). Conclusion: Reserpine increased oxidative stress and decreased antioxidant capacity in gastric and duodenum tissues. TQ and citalopram+TQ treatment decreased oxidative stress and increased antioxidant capacity in gastric and duodenum tissues. TQ and citalopram+TQ treatments proved to be more effective in protection from oxidative stress caused by reserpine in gastric and duodenum tissues than citalopram treatment.

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Section: Discussionmentioning

confidence: 99%

Effects Of Thymoquinone and Citalopram On Oxidative Stress in Gastric and Duodenum Tissue in Reserpinized Rats

Kuzay¹

2019

Erciyes Med J

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“…While RA is a prominent risk factor for kidney dysfunction, use of NSAIDs to manage RA often pre-dispose to this. 49 Accordingly, the suitability of medicinal agents can also be justified by estimating their capacity to protect the kidney function. Urea and creatinine are routinely excreted by kidney.…”

Section: Discussionmentioning

confidence: 99%

Complimentary Effects of Curcumin for Enhancing Efficacy of Acetylsalicylic Acid against Prostate Cancer

Mohapatra¹,

Mohapatra²,

Subudhi³

2019

IJPER

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Background: Prostate cancer is the 6 th leading cause of cancer death worldwide. Androgen Deprivation Therapy (ADT) in prostate cancer enhances the risk of Rheumatoid Arthritis (RA). Acetylsalicylic Acid (ASA) can be potentially repurposed against prostate cancer and arthritis. However, its efficacy is low and use is associated with nephrotoxicity as well as gastrotoxicity. Curcumin with reported ability to potentiate anti-inflammatory effects and reduce oxidative stress, can be used as a complementary therapy to enhance efficacy of ASA against prostate cancer and arthritis. This can also minimise ASA induced nephrotoxicity and gastrotoxicity. Aim and Objectives: To evaluate the ability of curcumin to enhance efficacy of ASA against prostate cancer, arthritis while minimising its adverse effects. Methods: In-vitro anticancer activity was assessed in DU-145 (Androgen-independent) and LNCaP (Androgen-dependent) cells. Effect against arthritis was evaluated in complete Freund's adjuvant (CFA) induced arthritis model in rats. Biochemical factors, radiology and histopathology were examined. Protection against kidney dysfunction and ulceration was determined. Results: Curcumin on co-administration with ASA (ASA+Cur) (25 µM + 25 µM) showed higher efficacy against DU-145 and LNCaP cell model. This co-use showed significant (p<0.001) inhibition of arthritis index (AI). The erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF) were significantly (p<0.001) decreased from their elevated level. It also reduced tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and interleukin 6 (IL-6) at the molecular level. While it showed moderate gastro-protection, there was no adverse effect on kidney functions. Conclusion: Curcumin seems to enhance the effect of ASA against androgen dependent as well as androgen independent prostate cancer while reducing arthritis. Simultaneously, it reduces ASA induced gastrotoxicity and prevents nephrotoxicity.

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“…The protective role of thymoquinone against gastrointestinal and renal toxicity of DIC has been demonstrated. This observation was mainly due to significant antioxidant capacity enhancement in gastrointestinal and renal tissues . Furthermore, it has reported the renoprotective role of Kolaviron with high antioxidant and anti‐inflammatory properties on rat models with DIC‐induced acute renal failure …”

Section: Introductionmentioning

confidence: 97%

Ondansetron enhanced diclofenac‐induced nephrotoxicity in mice

Shakibaie

Forootanfar

Ghaseminejad

et al. 2019

J Biochem & Molecular Tox

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This study was performed to investigate the effect of ondansetron, a serotonin receptor (5‐HT3) antagonist, in the alleviation of diclofenac‐induced kidney injuries. NMRI mice were randomly divided into six groups and treated with (A) untreated control group, (B) diclofenac (100 mg/kg), (C) ondansetron (1 mg/kg), (D to F) ondansetron (0.1, 0.5, and 1 mg/kg, respectively) and diclofenac (100 mg/kg) for last 3 days of experiment. The oxidative stress tests strongly demonstrated the negative synergistic effects of diclofenac and ondansetron, regarding the observation of dose‐dependent enhancement of malondialdehyde concentration, and reduction of glutathione content, and superoxide dismutase and catalase activity. Histopathological analyses revealed dose‐dependent tubular epithelial cells degeneration, outstanding mononuclear cells infiltration, clear necrosis at the papillary region of kidney, dilation, and vascular hyperemia in mice kidney tissues treated with ondansetron and diclofenac. Conclusively, these findings suggested the possible ondansetron‐diclofenac interaction through the induction of oxidative stress.

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Diclofenac induced gastrointestinal and renal toxicity is alleviated by thymoquinone treatment

Cited by 61 publications

References 48 publications

Effects Of Thymoquinone and Citalopram On Oxidative Stress in Gastric and Duodenum Tissue in Reserpinized Rats

Effects Of Thymoquinone and Citalopram On Oxidative Stress in Gastric and Duodenum Tissue in Reserpinized Rats

Complimentary Effects of Curcumin for Enhancing Efficacy of Acetylsalicylic Acid against Prostate Cancer

Ondansetron enhanced diclofenac‐induced nephrotoxicity in mice

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