Diclofenac in the treatment of pain in patients with rheumatic diseases

Abstract

Diclofenac, a phenylacetic acid derivative, is a drug demonstrating high efficacy after oral administration in the treatment of pain and physical disability in rheumatic diseases. In view of the adverse effects associated with using diclofenac, it is necessary to consider all known drug safety information before the drug is selected for therapy and the dosage regimen is set for individual patients. Selecting an oral dosage form with specific properties determined by excipients is a method to improve the availability of the drug substance and, at the same time, minimize adverse drug reactions. An alternative to tablet or capsule dosage forms is diclofenac application to the skin. The proven efficacy of this method is further improved through the use of transdermal penetration enhancers and vehicle ingredients which provide dosage forms with specific physical properties.

Ondansetron enhanced diclofenac‐induced nephrotoxicity in mice

“…DIC with several anti‐inflammatory, antipyretic, and analgesic properties is widely being used for the treatment of inflammatory disease like rheumatoid arthritis, spondylitis ankylosing, and post‐operative and post‐chemoradiotherapy inflammations. Unfortunately, besides the therapeutic benefits of DIC administration, its chronic uses induced nephrotoxicity and renal failure .…”

“…DIC with several anti-inflammatory, antipyretic, and analgesic properties is widely being used for the treatment of inflammatory disease like rheumatoid arthritis, [19,20] spondylitis ankylosing, [21] and post-operative [22,23] and post-chemoradiotherapy inflammations.…”

Tramadol/Diclofenac Fixed-Dose Combination: A Review of Its Use in Severe Acute Pain

“…The pharmacodynamic properties of tramadol and diclofenac have been reviewed extensively elsewhere [36][37][38][39][40][41][42][43][44][45]. The key pharmacodynamic properties of both of these analgesic agents are described below.…”

“…In vitro studies indicate that diclofenac has no significant effect on the serum protein binding of acenocoumarol, prednisolone, salicylic acid, tolbutamide, or warfarin [45]. Concomitant administration of antiplatelet medication and anticoagulants with diclofenac could increase the risk of bleeding [45,57]. If used concurrently, diclofenac may raise plasma concentrations of lithium by 26%, with a potential risk of intoxication [43].…”

Penggunaan Non-Steroid Antiinflamatory Drug dan Potensi Interaksi Obatnya Pada Pasien Muskuloskeletal

“…Penggunaan tunggal atau kombinasi dengan obat lain dari kelas yang berbeda terbukti efektif mengurangi nyeri akut dan kronis pada pasien muskuloskeletal 15 . Jika dibandingkan dengan parasetamol, NSAID lebih baik dalam menghilangkan nyeri pada penderita osteoarthritis, tetapi profil keamanannya lebih baik parasetamol 16,17 .…”