Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis

Zeng, Ni; Wen, Yihong; Pan, Rong; Yang, Jing; Yan, Yu-Min; Zhao, An-Zhi; Zhu, Ji-Xiao; Fang, Xianhong; Shan, Zhi

doi:10.1007/s12265-021-10116-w

Cited by 11 publications

(9 citation statements)

References 29 publications

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“…The expression of NFKBIZ was up-regulated in the H37Rv infection group relative to the CELL group, but there was no difference between the H37RvΔ1759c infection group and the CELL group. The regulation of miR-25 expression by the NFκB signaling pathway has also been reported in the relevant literature ( Zeng et al., 2021 ). These results suggest that the unchanged expression of miR-25 during H37RvΔ1759c infection may be caused by the unchanged expression of NFKBIZ, which affects the normal function of NFκB.…”

Section: Resultsmentioning

confidence: 61%

MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1

Wang

Feng

et al. 2022

iScience

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Section: Resultsmentioning

confidence: 61%

MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1

Wang

Feng

et al. 2022

iScience

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“…miRNAs also have an important role in the crosstalk mentioned above. For instance, miR-25-3p can target Dickkopf (DKK), a regulator of Wnt signaling, and activate Smad3 and fibrosis-related gene expression [ 63 ]. The study also proved that in cardiac fibrosis, the NF-κB signaling pathway could upregulate the expression level of miR-25-3p, suggesting that the crosstalk between signaling pathways in cardiac fibrosis could be associated with miRNAs.…”

Section: The Functions Of Mirnas In Cardiac Fibrosis-related Signalin...mentioning

confidence: 99%

New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies

Zhao

Chen

et al. 2022

Genes

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Cardiac fibrosis is a significant global health problem associated with almost all types of heart disease. Extensive cardiac fibrosis reduces tissue compliance and contributes to adverse outcomes, such as cardiomyocyte hypertrophy, cardiomyocyte apoptosis, and even heart failure. It is mainly associated with pathological myocardial remodeling, characterized by the excessive deposition of extracellular matrix (ECM) proteins in cardiac parenchymal tissues. In recent years, a growing body of evidence demonstrated that microRNAs (miRNAs) have a crucial role in the pathological development of cardiac fibrosis. More than sixty miRNAs have been associated with the progression of cardiac fibrosis. In this review, we summarized potential miRNAs and miRNAs-related regulatory mechanisms for cardiac fibrosis and discussed the potential clinical application of miRNAs in cardiac fibrosis.

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“…-Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis, by Ni Zeng and colleagues [12].…”

Section: Highly Commended Papers In Jctr In 2021mentioning

confidence: 99%

Best Paper of the Year 2021

Xiao

Lara‐Pezzi

2022

J. of Cardiovasc. Trans. Res.

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We are excited to present a new section in JCTR that highlights the best papers of the previous year. The following articles were selected by the associate editors from those accepted during 2021 and based on their relevance, impact, and how they contribute to the Journal's aims. We believe that they showcase the quality and diversity of the papers published in JCTR. Best Paper of the Year-Aged monkeys fed a high-fat/high-sugar diet recapitulate metabolic disorders and cardiac contractile dysfunction, by Shuang Zheng and colleagues [1].

show abstract

Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis

Cited by 11 publications

References 29 publications

MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1

MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1

New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies

Best Paper of the Year 2021

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