Dichotic phase effects on frequency following responses reveal phase variant and invariant harmonic distortion products

Gnanateja, G. Nike; Maruthy, Sandeep

doi:10.1016/j.heares.2019.04.008

Cited by 7 publications

(2 citation statements)

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“…Research spanning three decades has richly characterized the properties of subcortical FFRs (5,12,15,16,60,61). However, significantly less is known about the cortical FFR.…”

Section: Discussionmentioning

confidence: 99%

“…Periodicity, a critical cue for time-varying pitch(1-3) can be non-invasively assayed using the scalp-recorded frequency following responses (FFRs) in animal (4)(5)(6) and human models (1,(6)(7)(8)(9)(10)(11)(12)(13)(14)14,15). Scalp-recorded FFRs reflect phase-locked activity from neural ensembles across the ascending auditory pathway (16)(17)(18) and provide an integrative and non-invasive snapshot of pitch encoding in neurotypical and clinical populations (1,(6)(7)(8)(9)(10)(11)(12)(13)(14)14,15). In neurotypical populations, FFRs have been leveraged to demonstrate experience-dependent shaping of pitch patterns at pre-attentive stages of auditory processing.…”

Section: Introductionmentioning

confidence: 99%

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Deconstructing the Cortical Sources of Frequency Following Responses to Speech: A Cross-species Approach

Gnanateja

Rupp

Llanos

et al. 2021

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Time-varying pitch is a vital cue in the processing of speech signals. Neural processing of time-varying pitch cues in speech has been extensively assayed using scalp-recorded frequency-following responses (FFRs), which are thought to reflect integrated phase-locked activity from neural ensembles exclusively along the subcortical auditory pathway. Emerging evidence however suggests that the auditory cortex contributes to the FFRs as well. However, the response properties and the relative cortical contribution to the scalp-recorded FFR are only beginning to be explored. Here we used direct intracortical recordings from human subjects and animal models (macaque, guinea pig) to deconstruct the cortical sources of FFRs and leveraged representational similarity analysis as a translational bridge to characterize similarities between the human and animal models. We found robust FFRs in the auditory cortex that emerged from the thalamorecepient layers of the auditory cortex and contributed to the scalp-recorded FFRs via volume conduction.

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“…Research spanning three decades has richly characterized the properties of subcortical FFRs (5,12,15,16,60,61). However, significantly less is known about the cortical FFR.…”

Section: Discussionmentioning

confidence: 99%