Dichotic listening and corpus callosum magnetic resonance imaging in relapsing-remitting multiple sclerosis with emphasis on sex differences.

Gadea, Marién; Martí‐Bonmatí, Luis; Arana, Estanislao; Espert, Raúl; Casanova, Ventura; Pascual, Ana

doi:10.1037/0894-4105.16.2.275

Cited by 38 publications

(22 citation statements)

References 33 publications

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“…Moreover, studies in patients with multiple sclerosis have revealed a reduced LE report, which correlated with the extent of atrophy of the posterior part of the CC (Barkhof et al, 1998; Pelletier et al, 2001; Gadea et al, 2002). These results indicate that the perception of CV-syllables presented to the LE depends on the integrity of interhemispheric auditory pathways.…”

Section: Interhemispheric Auditory Connectivity In Healthy Controls (Hc)mentioning

confidence: 96%

Interhemispheric auditory connectivity: structure and function related to auditory verbal hallucinations

Steinmann

Leicht

Mulert

2014

Front. Hum. Neurosci.

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Auditory verbal hallucinations (AVH) are one of the most common and most distressing symptoms of schizophrenia. Despite fundamental research, the underlying neurocognitive and neurobiological mechanisms are still a matter of debate. Previous studies suggested that “hearing voices” is associated with a number of factors including local deficits in the left auditory cortex and a disturbed connectivity of frontal and temporoparietal language-related areas. In addition, it is hypothesized that the interhemispheric pathways connecting right and left auditory cortices might be involved in the pathogenesis of AVH. Findings based on Diffusion-Tensor-Imaging (DTI) measurements revealed a remarkable interindividual variability in size and shape of the interhemispheric auditory pathways. Interestingly, schizophrenia patients suffering from AVH exhibited increased fractional anisotropy (FA) in the interhemispheric fibers than non-hallucinating patients. Thus, higher FA-values indicate an increased severity of AVH. Moreover, a dichotic listening (DL) task showed that the interindividual variability in the interhemispheric auditory pathways was reflected in the behavioral outcome: stronger pathways supported a better information transfer and consequently improved speech perception. This detection indicates a specific structure-function relationship, which seems to be interindividually variable. This review focuses on recent findings concerning the structure-function relationship of the interhemispheric pathways in controls, hallucinating and non-hallucinating schizophrenia patients and concludes that changes in the structural and functional connectivity of auditory areas are involved in the pathophysiology of AVH.

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Section: Interhemispheric Auditory Connectivity In Healthy Controls (Hc)mentioning

confidence: 96%

Interhemispheric auditory connectivity: structure and function related to auditory verbal hallucinations

Steinmann

Leicht

Mulert

2014

Front. Hum. Neurosci.

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“…The corpus callosum deficit theory (Goldstein & Braun, 1974) proposes that age-related decrease of corpus callosum size causes less efficient transmission of the information from the LE to the language-dominant left hemisphere and thereby results in decreased LE performance in elderly. Indeed, callosal size has been found to decrease with age (Doraiswamy et al, 1991;Sullivan et al, 2001;Weis, Jellinger, & Wenger, 1991) and to correlate with performance on dichotic listening tasks in healthy participants (Clarke, Lufkin, & Zaidel, 1993;O'Kusky et al, 1988;Yazgan, Wexler, Kinsbourne, Peterson, & Leckman, 1995) and in patients suffering from neurodegenerative diseases affecting white matter like multiple sclerosis (Gadea et al, 2002;Reinvang, Bakke, Hugdahl, Karlsen, & Sundet, 1994).…”

Section: Increased Asymmetry In Recall Performance In Elderlymentioning

confidence: 99%

Age Effects in Identifying and Localising Dichotic Stimuli: A Corpus Callosum Deficit

Gootjes

Strien

Bouma

2004

Journal of Clinical and Experimental Neuropsychology

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In the present study, dichotic listening performance of 31 older adults was compared with performance of 25 younger adults under free and focussed attention conditions. In addition to an age-related general decrease in performance, we observed in the focussed attention condition increased asymmetry in the elderly group: the decrease of recall performance was stronger for the left ear (LE) than for the right ear (RE), while the increase of localisation errors was greater for the RE than for the LE. Identifying and localising digits appear to be different processes mediated predominantly by the left and right hemisphere, respectively. Since agerelated reduced performance is strongest for the ear ipsilateral to the hemisphere dominant to that particular function, these findings may be ascribed to decline of corpus callosum functioning resulting in decreased interhemispheric interaction rather than to a selective decline of right hemisphere functions.Age-related decline in cognitive functioning in healthy older adults appears to be restricted to tasks that demand more effortful processing. On tasks demanding automatic processing, elderly adults perform similarly to younger adults. Agerelated decline most probably is a consequence of deficits in selective attention needed during effortful processing (Kinsbourne, 1980). In the present research, we studied age differences in dichotic listening performance. The dichotic listening test (DLT) is an excellent tool for examining age-related cognitive decline since it involves different degrees of attentional and memory processing.The DLT is a non-invasive procedure to study the lateralisation of cerebral functions. Kimura (1961) developed the standard DLT, in which pairs of spoken digits are presented through a headphone. In each trial, three digits are sequentially presented to the left ear (LE), while at the same time three other digits are sequentially presented to the right ear (RE). The participants are asked to report as many digits as possible after each trial. Kimura (1967) found that verbal stimuli presented to the RE are reported more accurately than verbal stimuli presented to the LE.According to the structural model proposed by Kimura (1967), this right-ear advantage (REA) is a consequence of the functional anatomical organisation of the central-auditory system and the cerebral representation of language functions. Although auditory information is processed in the

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“…The auditory symptoms in two patients were attributed to damage of the pontine olivocochlear bundle and were explained on the basis of abnormal findings of loudness discomfort levels, masked speech audiometry and MLD, obtained at different stages in the course of the illness, in conjunction with MRI findings (Cohen et al, 1988). More proximal auditory structures may also be affected by MS, including the corpus callosum, which impairs interhemispheric transmission of the auditory information and thus results in a consequent dysfunction in dichotic listening (Gadea et al, 2002;Musiek et al, 1989).…”

mentioning

confidence: 98%

Auditory Efferent Function Is Affected in Multiple Sclerosis

Coelho

Ćeranić²,

Prasher

et al. 2007

Ear &Amp; Hearing

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This study provides the evidence for a deficit of efferent auditory function in the majority of patients with MS. Taking into consideration the possible roles of the MOC system in processing of auditory information, abnormal MOC suppression in patients with MS may explain a variety of auditory presentations that are currently largely overlooked. This study also highlights the diagnostic value of the MOC suppression test as a site-of-lesion diagnostic test in MS and in identifying subtle brain stem lesions undetected by MRI, suggesting that subtle brain stem lesions may exist and that the MOC suppression test is sufficiently sensitive to detect them. Accordingly, the MOC suppression test may provide a tool for an early diagnosis of MS.

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Dichotic listening and corpus callosum magnetic resonance imaging in relapsing-remitting multiple sclerosis with emphasis on sex differences.

Cited by 38 publications

References 33 publications

Interhemispheric auditory connectivity: structure and function related to auditory verbal hallucinations

Interhemispheric auditory connectivity: structure and function related to auditory verbal hallucinations

Age Effects in Identifying and Localising Dichotic Stimuli: A Corpus Callosum Deficit

Auditory Efferent Function Is Affected in Multiple Sclerosis

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