Dichoptic multifocal visual evoked potentials identify local retinal dysfunction in age-related macular degeneration

Sabeti, Faran; James, Andrew; Essex, Rohan W.; Maddess, Ted

doi:10.1007/s10633-012-9366-6

Cited by 14 publications

(21 citation statements)

References 34 publications

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“…6 represent the left and right radial spokes of the visual stimuli (Fig. 2)and thus model the responses projected onto the cortical sheet as we have described in detail2032. The central two rows, representing the spokes of stimuli at polar angles ± 15 degrees off the horizontal meridian best illustrate the point.…”

Section: Resultsmentioning

confidence: 99%

“…Stimuli were temporally modulated to deliver sparse, pseudorandom, contrast reversing stimuli with a mean frequency of 2 stimuli/s/region. These sparse stimuli create responses about 15 times larger than conventional densely flickering mfVEP stimuli3132, with commensurate improvements in diagnostic power1920. The resulting signal to noise ratios are improved by about square root 15 allowing for shorter duration experiments.…”

Section: Methodsmentioning

confidence: 99%

“…Recording duration was 240 seconds divided into eight segments of 30 s, and subjects could rest between segments. Details of the exact stimuli have been given elsewhere20. Vision of the participants was corrected with trial lenses for their distance ametropia to within ± 1.5 dioptres.…”

Section: Methodsmentioning

confidence: 99%

“…The method was pioneered by others1314. Like multifocal electroretinograms (mfERGs)151617, and multifocal visual evoked potentials (mfVEPs)181920 mfPOP concurrently presents many visual stimuli, but the measured responses are video records of changes in the diameter of the pupils, obviating the need for electrodes. With current mfPOP methods both eyes are tested at the same time.…”

mentioning

confidence: 99%

“…The mfPOP and mfVEP tests were done on the same day for every subject. The mfVEP study of AMD has been partially published20, but in that publication we only examined responses from the few electrodes placed directly above the occipital cortex. The mfVEP study of T2D has not been published.…”

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confidence: 99%

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Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases

Sabeti

James

Carle

et al. 2017

Sci Rep

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Multifocal pupillographic objective perimetry (mfPOP) shows regions of slight hypersensitivity away from retinal regions damaged by diabetes or age-related macular degeneration (AMD). This study examines if such results also appear in multifocal visual evoked potentials (mfVEPs) recorded on the same day in the same patients. The pupil control system receives input from the extra-striate cortex, so we also examined evidence for such input. We recruited subjects with early type 2 diabetes (T2D) with no retinopathy, and patients with unilateral exudative AMD. Population average responses of the diabetes patients, and the normal fellow eyes of AMD patients, showed multiple regions of significant hypersensitivity (p < 0.05) on both mfPOP and mfVEPs. For mfVEPs the occipital electrodes showed fewer hypersensitive regions than the surrounding electrodes. More advanced AMD showed regions of suppression becoming centrally concentrated in the exudative AMD areas. Thus, mfVEP electrodes biased towards extra-striate cortical responses (surround electrodes) appeared to show similar hypersensitive visual field locations to mfPOP in early stage diabetic and AMD damage. Our findings suggest that hypersensitive regions may be a potential biomarker for future development of AMD or non-proliferative diabetic retinopathy, and may be more informative than visual acuity which remains largely undisturbed during early disease.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases

Sabeti

James

Carle

et al. 2017

Sci Rep

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Psychophysical, electrofunctional, and morphological evaluation in naïve neovascular AMD patients treated with intravitreal anti‐VEGF

Nebbioso,

Franzone,

Milanese

et al. 2024

Aging Medicine

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ObjectivesThe aim of this study was to investigate the retinal morpho‐functional characteristics of patients with neovascular wet age‐related macular degeneration (nAMD) treated with intravitreal injection (IV) of aflibercept (AFL).MethodsThe study was conducted on 35 patients previously diagnosed with type 1 nAMD who received a fixed‐dosing regimen of aflibercept injections over 12 months. The goal was to assess trends in visual abilities over time by measuring visual acuity (VA), contrast sensitivity (CS), visual evoked potentials (VEPs), and spectral domain‐optical coherence tomography (SD‐OCT). The same psychophysical, electro‐functional, and morphological tests administered at baseline (T0) were repeated 4 to 8 weeks after the last aflibercept injection (Tn), resulting in a total of six examinations.ResultsAt Tn, all subjects exhibited improved VA for both far and near distances compared to values detected at T0. Similarly, VEP amplitude and latency values at Tn showed a greater P100 improvement than those observed at T0. Additionally, the CS examination at Tn demonstrated improvement, particularly at high spatial stimulation frequencies. The Tn SD‐OCT results highlighted a reduction in macular thickness compared to T0 values.ConclusionsThis exploratory research indicates that intravitreal injections of AFL, following a fixed‐dosing regimen, represent a valuable therapeutic approach for enhancing visual performance. This conclusion is supported by comprehensive statistical analysis of psychophysical, electro‐functional, and morphological examinations within the same group of patients with nAMD, as demonstrated for the first time.

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Exploring the methods of data analysis in multifocal visual evoked potentials

et al. 2016

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For a comparison of amplitude data between groups of patients, the logSNR or SNR methods are preferred because of the smaller inter-subject variability. LogSNR or peak-to-peak methods have lower intra-subject variability, so are recommended for comparing an individual mfVEP to previous published normative data. This study establishes that the choice of mfVEP data analysis method can be used to decrease variability of the mfVEP results.

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Dichoptic multifocal visual evoked potentials identify local retinal dysfunction in age-related macular degeneration

Cited by 14 publications

References 34 publications

Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases

Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases

Psychophysical, electrofunctional, and morphological evaluation in naïve neovascular AMD patients treated with intravitreal anti‐VEGF

Exploring the methods of data analysis in multifocal visual evoked potentials

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