Dichlorvos Induced Autoimmune Hepatitis: A Case Report and Review of Literature

Abstract

Introduction:Drug-induced liver injury is a frequent cause of hepatic dysfunction. Several drugs have been identified to cause autoimmune hepatitis (AIH). Environmental chemicals are capable of triggering a certain degree of liver injury. However, toxin induced AIH is rare.Case Presentation:We reported a woman with chronic (long-term) exposures to dichlorvos, which resulted in liver injury and cirrhosis. She was diagnosed after a second liver biopsy, which was correlated with laboratory findings. At the same time, she experienced hepatic cortical blindness during her first admission.Conclusions:Chronic (long-term) exposures to dichlorvos can lead to AIH. A detailed inquiry of medical history and liver biopsy are necessary for the diagnosis of toxin-induced AIH. Corticosteroid therapy is associated with favorable evolution.

The Eyes Are Useless When the Mind Is Blind: A Rare Case of Anton-Babinski Syndrome in Hepatic Encephalopathy

“…Few cases have reported transient cortical blindness in hepatic encephalopathy. [1][2][3] However, the case above details the unaware vision loss by the patient, which has not been expressed in previous studies.…”

Immunotoxic role of organophosphates: An unseen risk escalating SARS-CoV-2 pathogenicity

“…Moreover, it can exacerbate progression of systemic lupus erythematosus which is an autoimmune disease with diverse clinical and immunological manifestations. Long-term exposure to dichlorvos can promote development of autoimmune hepatitis ( Zhao et al, 2015 ). Thus, OP compounds have certain implications for autoimmunity and organ damage.…”

Dichlorvos toxicity: A public health perspective

“…Zhao et al , (2015) reported a case of dichlorvos induced autoimmune hepatitis in a 49-year-old Chinese woman following chronic exposure to dichlorvos. The diagnosis was made two and a half years after initial symptoms of exposure.…”