Dichloromethane Extract of the Leaves of Arbutus pavarii Pamp. Exhibits Cytotoxicity Against the Prostate Cancer Cell Line PC3: A Bioassay-guided Isolation and Identification of Arbutin and Betulinic Acid Methyl Ester

Groshi, Afaf Al; Nahar, Lutfun; Ismail, Fyaz M.D.; Evans, Andrew R.; Sarker, Satyajit D.

doi:10.4274/tjps.galenos.2021.79353

Cited by 1 publication

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“…While the plants from the families, Asteraceae, Ericaceae, Proteaceae and Rosaceae are the main sources, to date, at least 45 other plant families have been reported to produce this glycoside (Table 1). In the Asteraceae, the genera Ainsliaea [7], Artemisia [20], Centaurea [46], Mutisia [80], Petasites [92], Podospermum [98] and Serratula [136] are known to produce arbutin (1), while the genera Arbutus [12], Arctostaphylos [15], Arctous [19], Calluna [17], Pyrola [101], Rhododendron [125] and Vaccinium [147] from the family Ericaceae are seven other major sources thereof (Table 1). Plants from at least seven genera within the Proteaceae, e.g., Bellendena [25], Cenarrhenes [25], Grevillea [59], Hakea [60], Heliciopsis [63], Leucadendron [73] and Persoonia [25] biosynthesize arbutin.…”

Section: Distribution Of Arbutin (1) In the Plant Kingdommentioning

confidence: 99%

“…In vitro [179,180] Cytotoxicity against the prostate cancer cell line PC3. [12] Miscellaneous Promotion of expression of miRNA-338-3p in suppressing cancer progression.…”

Section: Bladder Cancermentioning

confidence: 99%

“…Recently, a dichloromethane extract of the leaves of Arbutus pavarii was shown to possess cytotoxicity against the PC3 human prostate cancer cell line. Employing a bioassayguided isolation protocol, arbutin was isolated as one of the major bioactive compounds [12]. One in eight men in the UK is likely to have prostate cancer, which can develop when cells in the prostate start to grow in an uncontrolled way [196].…”

Section: Prostate Cancermentioning

confidence: 99%

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Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent

Nahar

Al-Groshi

Kumar³

et al. 2022

Molecules

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Arbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents. In addition to its skin whitening property, arbutin possesses other therapeutically relevant biological properties, e.g., antioxidant, antimicrobial and anti-inflammatory, as well as anticancer potential. This review presents, for the first time, a comprehensive overview of the distribution of arbutin in the plant kingdom and critically appraises its therapeutic potential as an anticancer agent based on the literature published until the end of August 2022, accessed via several databases, e.g., Web of Science, Science Direct, Dictionary of Natural Products, PubMed and Google Scholar. The keywords used in the search were arbutin, cancer, anticancer, distribution and hydroquinone. Published outputs suggest that arbutin has potential anticancer properties against bladder, bone, brain, breast, cervix, colon, liver, prostate and skin cancers and a low level of acute or chronic toxicity.

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Section: Distribution Of Arbutin (1) In the Plant Kingdommentioning

confidence: 99%

“…In vitro [179,180] Cytotoxicity against the prostate cancer cell line PC3. [12] Miscellaneous Promotion of expression of miRNA-338-3p in suppressing cancer progression.…”

Section: Bladder Cancermentioning

confidence: 99%

Section: Prostate Cancermentioning

confidence: 99%

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