Dichloroacetylaroylmethanes as two-carbon synthons in the Biginelli reaction

Abstract

Acid-catalyzed cyclocondensation in a three component system of dichloromethylacetylbenzoylmethanes, urea, and aromatic aldehydes occurred regio-and stereoselectively to give polyfunctional derivatives of perhydropyrimidine.

Aromatization of 1,3,5-Trisubstituted of 4,5-Dihydro-1H-Pyrazoles by In-Situ Generation of I+from Hydrogen Peroxide/Acids/Iodide Potassium or Sodium Systems

“…[37][38][39] However, we preferred hydrogen peroxide as oxidant over other available oxidizing agents since it is cheap, operationally safe, environmentally friendly, easy to handle and produces only water as a by product, which reduces purification requirements. [40][41][42][43] The HI is highly toxic and corrosive as harmful as molecular iodine to the environment.…”

Reactions of 6-aryl-5-benzoyl-4-dichloromethyl-4-hydroxy-hexahydropyrimidin-2-ones with hydrazine hydrate: A new simple and efficient route to 4-aryl-5-phenyl-3,4-dihydropyrimido[4,5- d]pyridazin-2(1 H)-ones

“…12 4,5 Diphenyl 3,4 dihydropyrimido[4,5 d]pyridazin 2(1H) one (2a). Hydrazine hydrate (85%, 1.54 g, 26.18 mmol) was added to a mixture of perhydropyrimidinone 1a (0.50 g, 1.31 mmol) in toluene (10 mL).…”

Microwave Assisted Synthesis of Pyrimidine Carboxamide Catalyzed by Ruthenium Chloride and their Antioxidant Studies

“…Biginelli reaction was carried out by mixing active 1,3dicarbonyl, different substituted aldehydes, and thiourea or urea is combined with different catalysts like ZrCl4 [14], Cu(OTf)2 [15], AcOH [16], CdCl2 [17], Ionic liquids [18], SiO2/H2SO4 [19], ion-exchange resin [20], La(OTf)3 [21], LiBr [22],p-TSA [23], (NH4)2Ce(NO3)6 [24], MgBr2 [25], InBr3 [26], ultrasound irradiation [27] microwave [28] and solvent-free conditions [29], ZnCl2/TBAB [30]. Co(NO3)2.6H2O [31], Mn(OAc)3 [32].…”