Dichlorido{N′-[1-(2-pyridin-2-yl)ethylidene]acetohydrazide-κ²N′,O}copper(II)

Abstract

In the title compound, [CuCl2(C9H11N3O)], the CuII atom is in a distorted square-pyramidal CuCl2N2O coordination geometry. The tridentate acetohydrazide ligand chelates in a meridional fashion. The chloride ligand in the axial position forms a long Cu—Cl distance of 2.4892 (9) Å. In contrast, the Cu—Cl distance from the equatorial chloride ligand is much shorter [2.2110 (7) Å]. Inter­molecular N—H⋯Cl and C—H⋯Cl hydrogen bonds link the complexes into a three-dimensional network.

ROS-Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells

“…2-Acetylpyridine acetylhydrazone (H2AcMe), 2-benzoylpyridine acetylhydrazone (H2BzMe) and complexes 1 and 2 were prepared as previously reported by some of us [13] and by other authors [14,15]. The synthetic routes for the ligands and their Cu(II) complexes are outlined in Scheme 1.…”

Dichlorido{N′-[(pyridin-2-yl)methylidene-κN]acetohydrazide-κ2N′,O}copper(II)

“…1), the copper(II) ion exhibits a distorted square pyramidal geometry. The N′-(pyridine-2-ylmethylene)acetohydrazide ligand is in its keto form as indicated by the short C-O distance of 1.235 2 The structure of a copper(II) dichloride complex with a similar tridentate hydrazone ligand has been reported in the literature (Datta, et al, 2011). For other related copper(II) complexes with similar tridentate ligands, see: Sen et al (2005Sen et al ( , 2007a, Ray et al (2008a,b), Recio Despaigne et al 2009; Datta et al (2010a,b).…”

End‐to‐End Thiocyanato‐Bridged Helical Chain Polymer and Dichlorido‐Bridged Copper(II) Complexes with a Hydrazone Ligand: Synthesis, Characterisation by Electron Paramagnetic Resonance and Variable‐Temperature Magnetic Studies, and Inhibitory Effects on Human Colorectal Carcinoma Cells

“…N ′-[1-(pyridin-2-yl)ethylidene]acetohydrazide (HL) : As described previously,[ 17 ] acetylhydrazide (0.074 g, 1.0 mmol) was reacted with 2-acetylpyridine (0.112 mL, 1.0 mmol) in MeOH (15 mL). After 2 h at reflux, the pale yellow methanolic salt was cooled to RT.…”

“…The ligand HL was obtained from an aliphatic hydrazone ligand as described previously by condensation of acetic hydrazide with 2-acetylpyridine ( Scheme 1 ). [ 17 ] The present paper describes the synthesis and full characterisation of these two new copper(II) complexes 1 and 2 by IR, UV–vis and electron paramagnetic resonance (EPR) spectroscopies, single-crystal X-ray diffraction analysis and variable-temperature magnetic susceptibility studies. Moreover, the potential anticancer properties of 1 and 2 have been examined through cell-growth inhibition assays using human colorectal carcinoma cells (COLO-205 and HT-29).…”