Dichloramin—t and Petrolatum Dressing for Burns

Abstract

The results of necropsies in nineteen cases of pernicious anemia at the Massachusetts General Hospital between 1908 and 1919 are given in the accompanying table.

A Comparative Study of the Local Anesthetic Potencies and Toxicities of Beta-Diethylaminoethyl Cumate and Procaine**College of Pharmacy, University of Florida, Gainesville

“…The trypan blue test confirmed the fact that 0-diethylaminoethyl cumate HCI was actually considerably more irritating than procaine HC1 since i t required approximately five times the concentration of the latter drug to produce a degree of irritation corresponding to that for the cumic acid ester. 4.…”

“…it became evident that besides the known glycosides of digitalis there are many other glycosidal substances present which have not been isolated and characterized. During the past few years, several new glycosides, gitorin (l), strospeside (2, 3), digipurpurin (4), digifolein (4), glucogitofucoside (4), gitaloxin ( 5 ) , verodoxin (F), digiproside (7), and diginatin (S), have been isolated. In this paper we shall describe another glycoside which has not been previously isolated and which we have obtained from extracts of D. Zunatu.…”

“…The usual procedure was to make 3 injections of a given concentration of the drug across the arm, test these for anesthesia, then make another series of 3 injections using a different concentration and so on for a total, in most instances, of 9 injections representing 3 concentrations of drug. I n testing for anesthesia, two types of stimuli were employed : ( a ) a sewing needle to test the response to pain, following the method of McIntyre and Sievers (3) and ( b ) a wisp of cotton, twisted to a fine point, to test the response to touch according to the method of Sollmann (4). All tests were made a t two-minute intervals until the absence of anesthesia was definitely established.…”

Dialkylaminoethyl Esters of 4-Nitro- and 4-Amino- 3 -hydroxy-2 -naphthoic Acids***Research Laboratories of the Heyden Newport Chemical Corp., Garfield, N. J.

“…2-Diethylaminoethyl 4-Amino-3-hydroxy-2naphthoate Hydrochloride (HI).-Twelve grams (0.0326 mole) of 2-diethylaminoethyl 4-nitro-3hydroxy-2-naphthoate hydrochloride (11) The methyl ester of 3-hydroxy-2-naphthoic acid (IV) was nitrated in acetic acid by essentially the same procedure as described by Gradenwitz (2). The mononitro compound was isolated as yellow crystalline needles melting 186 to 189" in a 30y6 yield.…”

“…Synthesis of the proposed ring-substituted amino derivative of 2-diethylaminoethyl 3-hydroxy-2-naphthoate was accomplished by nitrating the hydrochloride of this ester (I) in glacial acetic acid under the same conditions described by Gradenwitz (2) for the preparation of methyl 4-nitro-3-hydroxy-2-naphthoate (V) and subsequent reduction of the nitro derivative (11) to the corresponding amino compound (111) by catalytic hydrogenation.…”