Dicationic derivatives of dinaphthotetraaza[14]annulene: synthesis, crystal structures and the preliminary evaluation of their DNA binding properties

Synthesis, functionalization and coordination chemistry of dibenzotetraaza[14]annulenes

“…The O-alkylation of 83 with 1,4dibromobutane led to the intermediate 84a (Scheme 20) [80]. A similar strategy was also reported for the decoration of 83 with various alkyl chains [81][82][83][84][85][86]. Next, a reaction of 84a with The synthetic strategy was extended by synthesizing a DBTAA zinc(II) complex connected through a linear octane chain linker.…”

“…The co-facial dimeric 86 was synthesized from an alkylation reaction between 83 and 84a in DMF over a week. On the other hand, the warm heating of 83 with intermediate 85 [81,87] at 70 ºC afforded the non-symmetric dimer 87 in 37% yield. Further, the metalation of 86 with Zn(OAc)2 afforded the complex 88 in 67% yield.…”