Dicarbonyl/l-xylulose reductase (DCXR): The multifunctional pentosuria enzyme

Lee, Sun Kyung; Son, Le Tho; Choi, Hee Jung; Ahnn, Joohong

doi:10.1016/j.biocel.2013.08.010

Cited by 19 publications

(13 citation statements)

References 29 publications

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“…DCXR is a member of the formation of xylulose-5-phosphate pathway with the main function of converting L-xylulose to xylitol. Deficiency in DCXR is linked to pentosuria, a condition characterized by high L-xylulose levels in urine (27). We found strong positive correlations of tubular DCXR expression to other members of the formation of xylulose-5-phosphate pathway in our study.…”

Section: Discussionsupporting

confidence: 66%

Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease

Perco

Kerschbaum

et al. 2019

JCI Insight

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Section: Discussionsupporting

confidence: 66%

Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease

Perco

Kerschbaum

et al. 2019

JCI Insight

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“…In particular, DCXR is well conserved through evolution and encodes dicarbonyl l-xylulose reductase, a member of the shortchain dehydrogenase/reductase superfamily, which reduces various α-dicarbonyl compounds involved in the formation of advanced glycation end products (Nakagawa et al, 2002). Dicarbonyl compounds originate from sugars or lipids and are generated in various biological systems by oxidative stress (Lee et al, 2013). PCYT2 encodes ethanolamine-phosphate cytidylyltransferase 2 involved in the synthesis of phosphatidylethanolamine from diacylglycerol.…”

Section: Pathway Analysis Resultsmentioning

confidence: 99%

Genome-wide association study of milk fatty acid composition in Italian Simmental and Italian Holstein cows using single nucleotide polymorphism arrays

Palombo

Milanesi

Sgorlon

et al. 2018

Journal of Dairy Science

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Bovine milk is important for human nutrition, but its fat content is often criticized as a risk factor in cardiovascular disease. Selective breeding programs could be used to alter the fatty acid (FA) composition of bovine milk to improve the healthiness of dairy products for human consumption. Here, we performed a genome-wide association study (GWAS) on bovine milk to identify genomic regions or specific genes associated with FA profile and to investigate genetic differences between the Italian Simmental (IS) and Italian Holstein (IH) breeds. To achieve this, we first characterized milk samples from 416 IS cows and 436 IH cows for their fat profile by gas chromatography. Subjects were genotyped with single nucleotide polymorphism array and a single-marker regression model for GWAS was performed. Our findings confirm previously reported quantitative trait loci strongly associated with bovine milk fat composition. More specifically, our GWAS results revealed significant signals on chromosomes Bos taurus autosome 19 and 26 for milk FA. Further analysis using a gene-centric approach and pathway meta-analysis identified not only some well-known genes underlying quantitative trait loci for milk FA components, such as FASN, SCD, and DGAT1, but also other significant candidate genes, including some with functional roles in pathways related to "Lipid metabolism." Highlighted genes related to FA profile include ECI2, PCYT2, DCXR, G6PC3, PYCR1, and ALG12 in IS, and CYP17A1, ACO2, PI4K2A, GOT1, GPT, NT5C2, PDE6G, POLR3H, and COX15 in IH. Overall, the breed-specific association outcomes reflect differences in the genetic backgrounds of the IS and IH breeds and their selective breeding histories.

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“…Sorbitol dehydrogenase (SORD) is an enzyme in carbohydrate metabolism converting sorbitol, the sugar alcohol form of glucose, into fructose [ 70 ]. Dicarbonyl/L-xylulose reductase (DCXR) is involved in carbohydrate metabolism and glucose metabolism which is a highly conserved and phylogenetically widespread enzyme converting L-xylulose into xylitol [ 71 ]. This shows that proteins in carbohydrate metabolism make contribution to provide energy for the body by participating in carbohydrate metabolism.…”

Section: Resultsmentioning

confidence: 99%

The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis

Zheng

Zhang

Qiao

2015

Evidence-Based Complementary and Alternative Medicine

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Qishen Yiqi formula (QSYQ) has the effect of tonifying Qi and promoting blood circulation, which is widely used to treat the cardiovascular diseases with Qi deficiency and blood stasis syndrome. However, the mechanism of QSYQ to tonify Qi and promote blood circulation is rarely reported at molecular or systems level. This study aimed to elucidate the mechanism of QSYQ based on the protein interaction network (PIN) analysis. The targets' information of the active components was obtained from ChEMBL and STITCH databases and was further used to search against protein-protein interactions by String database. Next, the PINs of QSYQ were constructed by Cytoscape and were analyzed by gene ontology enrichment analysis based on Markov Cluster algorithm. Finally, based on the topological parameters, the properties of scale-free, small world, and modularity of the QSYQ's PINs were analyzed. And based on function modules, the mechanism of QSYQ was elucidated. The results indicated that Qi-tonifying efficacy of QSYQ may be partly attributed to the regulation of amino acid metabolism, carbohydrate metabolism, lipid metabolism, and cAMP metabolism, while QSYQ improves the blood stasis through the regulation of blood coagulation and cardiac muscle contraction. Meanwhile, the “synergy” of formula compatibility was also illuminated.

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Dicarbonyl/l-xylulose reductase (DCXR): The multifunctional pentosuria enzyme

Cited by 19 publications

References 29 publications

Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease

Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease

Genome-wide association study of milk fatty acid composition in Italian Simmental and Italian Holstein cows using single nucleotide polymorphism arrays

The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis

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