Dicaffeoylquinic Acids from the Aerial Parts of Artemisia ciniformis Krasch. & Popov ex Poljakov

Abstract

Background: Artemisia ciniformis (A. ciniformis) belongs to the genus Artemisia and grows at northeast of Iran. The current phytochemical study was carried out on the most potent extract in cell-free antioxidant assays. Methods: Hydroethanolic extract of the aerial parts was fractionated using vacuum-liquid chromatography (VLC). The selected fraction from the previous cell-free antioxidant study was purified by semi-preparative HPLC. The structures of isolated compounds were identified using one- and two-dimensional NMR and ESIMS techniques. Results: Three identified compounds in this study were the known isomers of dicaffeoylquinic acid (DCQ), including 3,5- DCQ (isochlorogenic acid A), 3,4-DCQ (isochlorogenic acid B) and 4,5-DCQ (isochlorogenic acid C). Conclusion: The outstanding free radical scavenging potential in the hydroethanolic extract of A. ciniformis might be partly related to the presence of isochlorogenic acid derivatives.

Chemical Constituents of the Artemisia ciniformis Aerial Parts Grown in the Northeast of Iran and Their Chemotaxonomic Significance

“…Various investigations have been conducted on the Artemisia genus, revealing the presence of different categories of metabolites, mainly phenolics (including glycosylated and unglycosylated flavonoids, tannins, and phenolic acids), terpenoids (such as monoterpenes, sesquiterpenes, and diterpenes), and alkaloids (31). Additionally, other compounds like coumarins, caffeoylquinic acids, sterols, polyketides, fatty acids, carbohydrates, proteins, and acetylenes have also been reported (1,31,32). Given that Artemisia belongs to the Asteraceae family, it is assumed that A. ciniformis is also rich in essential oils.…”