Dibutyl-phthalate exposure from mesalamine medications and serum thyroid hormones in men

Nassan, Feiby L.; Korevaar, Tim I M; Coull, Brent A.; Skakkebæk, Niels E.; Krawetz, Stephen A.; Estill, Molly; Hait, Elizabeth J.; Korzenik, Joshua R.; Ford, Jennifer B.; Poortere, Ralph A de; Broeren, Maarten A. C.; Moss, Alan C.; Zoeller, Thomas; Hauser, Russ

doi:10.1016/j.ijheh.2018.08.008

Cited by 24 publications

(9 citation statements)

References 44 publications

(62 reference statements)

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“…For human studies, a randomized controlled approach can generally not be undertaken for proven EDsalthough this has in a few cases been done, e.g. in a randomized control trial with low dose bisphenol A exposure due to drinking from cans [101] or in the case of the effects of a phthalate on male health [102,103]. Here, the main approach used to tackle multifactorial diseases is that the other factors influencing the disease and also possibly associated with ED exposure (the potential confounders in the epidemiological terminology) are measured and controlled for by statistical tools such as multiple regression models 10 , which can, with some assumptions, provide estimates of the association between the exposure and the health outcome as if exposure had been randomized.…”

Section: Efficient Methodologies To Highlight the Cause Of Multifactorial Diseases Existmentioning

confidence: 99%

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Mikroplastik: vom Tiegel auf den Teller

Saha¹

2021

Dtsch Dermatolog

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This study, commissioned by the PETI Committee of the European Parliament, presents the scientific knowledge regarding the health effects of endocrine disruptors, a class of hazards recognized in EU regulation since 1999. This report reviews the scientific evidence regarding the concept of endocrine disruption, the extent of exposure, associated health effects and costs. The existing relevant EU regulations are discussed and recommendations made to better protect human health. ABOUT THE PUBLICATIONThis research paper was requested by the European Parliament's Committee on Petitions and commissioned, overseen and published by the Policy Department for Citizen's Rights and Constitutional Affairs.Policy Departments provide independent expertise, both in-house and externally, to support European Parliament committees and other parliamentary bodies in shaping legislation and exercising democratic scrutiny over EU external and internal policies.

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Section: Efficient Methodologies To Highlight the Cause Of Multifactorial Diseases Existmentioning

confidence: 99%

“…Both animal studies and epidemiology have linked phthalates to the developmental neurotoxicity of DEHP (see for instance [133,134]). Regarding DBP, in adults, a recent experiment reported a possible disruption of the thyroid axis in men following DBP exposure [103].…”

Section: Phthalatesmentioning

confidence: 99%

Mikroplastik: vom Tiegel auf den Teller

Saha¹

2021

Dtsch Dermatolog

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“…The most commonly used phthalates include di-n-butyl phthalate (DBP), di-2-ethyl-hexyl phthalate (DEHP) and dimethyl-phthalate (DMP) and, since most phthalates are not firmly bound to their matrix (notably the case for DEHP [57]), they can be transferred to and contaminate other substances, making phthalate exposure in humans ubiquitous in the EU population [58][59][60]. At the molecular level, DEHP has been shown to interact with AR displaying anti-androgen effects, PPAR receptors and aryl-hydrocarbon receptor (AhR) [61] and, as also for DBP exposure [62], disrupt the thyroid axis by influencing thyroid hormone cellular uptake and distribution [63].…”

Section: Edcs' Molecular Mechanisms: From Dichlorodiphenyltrichloroetmentioning

confidence: 99%

Endocrine-Disrupting Chemicals’ (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1

Buoso

Masi

Racchi

et al. 2020

IJMS

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Endocrine disruptors (EDCs) can display estrogenic and androgenic effects, and their exposure has been linked to increased cancer risk. EDCs have been shown to directly affect cancer cell regulation and progression, but their influence on tumour microenvironment is still not completely elucidated. In this context, the signalling hub protein RACK1 (Receptor for Activated C Kinase 1) could represent a nexus between cancer and the immune system due to its roles in cancer progression and innate immune activation. Since RACK1 is a relevant EDCs target that responds to steroid-active compounds, it could be considered a molecular bridge between the endocrine-regulated tumour microenvironment and the innate immune system. We provide an analysis of immunomodulatory and cancer-promoting effects of different EDCs in shaping tumour microenvironment, with a final focus on the scaffold protein RACK1 as a pivotal molecular player due to its dual role in immune and cancer contexts.

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“…Importantly, evidence suggests that medication-associated DBP exposure disrupts hormonal axes. In a crossover-crossback study of patients treated with mesalamine for inflammatory bowel disease, conversion to mesalamine products containing DBP altered levels of thyroid hormones and antithyroid antibodies ( 7 ). Parabens are an emerging class of EDCs that disrupt multiple signaling pathways and hormone-dependent outcomes, including those related to sex steroids, glucocorticoids, and thyroid hormones, among others ( 1 ).…”

Section: Endocrine Disruptors In Medicationsmentioning

confidence: 99%

Unwitting Accomplices: Endocrine Disruptors Confounding Clinical Care

Genco

Anderson-Shaw

Sargis

2020

The Journal of Clinical Endocrinology &Amp; Metabolism

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Abstract Burgeoning evidence over the last 25 years has identified myriad synthetic chemicals with the capacity to alter various aspects of hormone synthesis and action. These endocrine-disrupting chemicals (EDCs) have been linked to various diseases, including reproductive disorders, metabolic diseases, and developmental abnormalities among others. Exposure to EDCs arises from industrial activity, use of personal and home care products, and consumption of contaminated food and water; however, the role of healthcare in exposing individuals to EDCs is grossly underappreciated. Indeed, through the use of medications as well as medical equipment and devices, healthcare providers are unknowing mediators of exposure to EDCs, chemicals that might not only promote disease but that may also antagonize the efficacy of treatments. The ethical implications of provider-dependent exposure are profound. A failure to disclose the endocrine-disrupting properties of medical interventions violates core principles of non-maleficence, patient autonomy, and justice as well as the practice of informed consent. Furthermore, physicians’ lack of knowledge regarding EDCs in medical practice artificially skews risk-benefit calculations that are fundamental to informed medical decision-making. To combat this underappreciated ethical challenge, urgent action is required. Healthcare providers must be educated about endocrine disruption. Known EDCs, defined by endocrinologists, should be clearly labeled on all medical products, and all medication components and devices should be screened for endocrine-disrupting properties. Finally, communication strategies must be devised to empower patients with knowledge about these risks. Providing ethically-competent care requires an open acknowledgment of endocrine risks imposed by the medical community that have heretofore been ignored.

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Dibutyl-phthalate exposure from mesalamine medications and serum thyroid hormones in men

Abstract: High-DBP novel exposure or removal from chronic high-DBP exposure could alter elements of the thyroid system, and most probably alters the peripheral T4 conversion to T3 and thyroid autoimmunity, consistent with thyroid disruption. After exposure removal, these trends were mostly reversed.

Cited by 24 publications

References 44 publications

Mikroplastik: vom Tiegel auf den Teller

Mikroplastik: vom Tiegel auf den Teller

Endocrine-Disrupting Chemicals’ (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1

Unwitting Accomplices: Endocrine Disruptors Confounding Clinical Care

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