( ±)-Dibrevianamides Q1 and Q2, the key precursors of asperginulin A from a marine-derived fungus

Zhao, Ying-Jie; Li, Lei; Zhang, Ya-Hui; Yang, Yun-Yi; Li, Long-Fei; Yang, Kan; Liu, Yun-Feng; Cao, Fei

doi:10.1007/s00253-023-12739-2

Appl Microbiol Biotechnol

2023

DOI: 10.1007/s00253-023-12739-2

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( ±)-Dibrevianamides Q1 and Q2, the key precursors of asperginulin A from a marine-derived fungus

Ying-Jie Zhao,

Lei Li,

Ya-Hui Zhang

et al.

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2024

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Recent Discovery of Nitrogen Heterocycles from Marine-Derived Aspergillus Species

Shi,

Yu,

Chen

et al. 2024

Marine Drugs

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Nitrogen heterocycles have drawn considerable attention because of their structurally novel and significant biological activities. Marine-derived fungi, especially the Aspergillus species, possess unique metabolic pathways to produce secondary metabolites with novel structures and potent biological activities. This review prioritizes the structural diversity and biological activities of nitrogen heterocycles that are produced by marine-derived Aspergillus species from January 2019 to January 2024, and their relevant biological activities. A total of 306 new nitrogen heterocycles, including seven major categories—indole alkaloids, diketopiperazine alkaloids, quinazoline alkaloids, isoquinoline alkaloids pyrrolidine alkaloids, cyclopeptide alkaloids, and other heterocyclic alkaloids—are presented in this review. Among these nitrogen heterocycles, 52 compounds had novel skeleton structures. Remarkably, 103 compounds showed various biological activities, such as cytotoxic, antimicrobial, anti-inflammatory, antifungal, anti-virus, and enzyme-inhibitory activities, and 21 compounds showed potent activities. This paper will guide further investigations into the structural diversity and biological activities of nitrogen heterocycles derived from the Aspergillus species and their potential contributions to the future development of new natural drug products in the medicinal and agricultural fields.

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Recent Discovery of Nitrogen Heterocycles from Marine-Derived Aspergillus Species

Shi,

Yu,

Chen

et al. 2024

Marine Drugs

View full text Add to dashboard Cite

show abstract

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( ±)-Dibrevianamides Q1 and Q2, the key precursors of asperginulin A from a marine-derived fungus

Cited by 1 publication

References 29 publications

Recent Discovery of Nitrogen Heterocycles from Marine-Derived Aspergillus Species

Recent Discovery of Nitrogen Heterocycles from Marine-Derived Aspergillus Species

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