Diblock copolymers of ethylene oxide and 1,2-butylene oxide in aqueous solution

Micellisation of triblock copolymers of ethylene oxide and 1,2-butylene oxide: Effect of B-block length

“…4b and shows transitions in slope at n t % 13 and n t % 30. Similar pairs of transitions have been noted [18] in related plots for diblock copolymers of ethylene oxide with DL-lactide or e-caprolactone.…”

“…4a can be satisfactorily represented by lines showing two transitions in slope, at n t % 14 and n t % 21. These results can be compared with the corresponding plot published [18] for diblock E m B n copolymers which is reproduced in Fig. 4b and shows transitions in slope at n t % 13 and n t % 30.…”

“…The effect of hydrophobic-block collapse on the block-length dependence of the critical concentration for micellisation has been investigated recently for diblock E m B n copolymers covering a range of B-block lengths from B 7 to B 76 , with transitions in the results assigned to the onset and completion of unimolecular micelle formation [18]. However, the possibility of related effects in the micellisation of B n E m B n copolymers in dilute solution has not been investigated since the range of hydrophobicity has been much restricted for those copolymers, i.e.…”

Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation

“…Polymerizations were performed in bulk, using alcohol- potassium alkoxide mixtures as initiators, resulting in narrow molecular weight distributions. In general, rather short PBO blocks were synthesized. − Several groups extensively explored the materials properties of the copolymers, focusing on the dependence of micellization and gelation behavior on the block architecture. − Following the trend in hydrophobicity, copolymers of EO and BO exhibit lower critical micelle concentrations than copolymers of EO with PO, even if the hydrophobic block is shorter (Figure ). In this context one may emphasize that low molecular weight PPO homopolymers are water-soluble below a critical solution temperature. , …”

Reverse poly(butylene oxide)–poly(ethylene oxide)–poly(butylene oxide) block copolymers with lengthy hydrophilic blocks as efficient single and dual drug-loaded nanocarriers with synergistic toxic effects on cancer cells

“…15 Hence, during the last few years, different block copolymer counterparts with similar architecture but with the PO segment replaced by a more hydrophobic one have been proposed with the aim of improving drug solubilization capacities and release proles. [16][17][18][19][20][21] Special attention has been paid to copolymers with 1,2-butylene oxide (BO) as the hydrophobic monomer due to its structural similarity to PO; moreover, the transfer is not a problem in the laboratory polymerization of BO. 22 This monomer (as does PO) adds to the growing chain to give a secondary oxyanion, and the slow initiation of EO chains at the secondary termination might lead to a broadened EO-block length distribution.…”