Diblock copolymer micelles as surface-functionalized particles and direct decoration of nanoparticles on their surface

Lee, Sang-Hwa; Kim, Hwan; Chae, Seungyong; Sohn, Byeong‐Hyeok

doi:10.1016/j.polymer.2015.01.067

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…'Smart' drug delivery systems have attracted much interest from pharmacologists and biomaterials scientists in previous decades, and amphiphilic polymers with the ability to selfassemble into micelles in aqueous solutions are highly promising. [1][2][3][4] Advantages of using polymeric micelles as drug carriers include relatively easy structural and functional modication, improved biodistribution and bioavailability of the drugs, and targeted delivery of drugs to correct locations such as tumor cells. [5][6][7][8] As most anticancer drugs have poor solubility, high side effects and low bioavailability, the encapsulation of anticancer drugs in polymeric micelles could not only improve the solubility of drugs, but also decrease the risk of multidrug resistance.…”

Section: Introductionmentioning

confidence: 99%

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

et al. 2016

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Phenylboronic and folate grafted chitosan hydrochloride (FHCSPBA) was synthesized and confirmed by FTIR and 1 H NMR.Glucose and pH dually responsive micelles were obtained through self-assembling of the amphiphilic polymer. The prepared FHCSPBA micelles displayed good biocompability and sustained drug release for the model drug doxorubicin hydrochloride (DOX). The cumulative drug release from the polymeric micelles showed obvious pH and glucose dependence and was accelerated by slightly decreasing the medium pH or increasing the glucose concentration. In vitro antitumor efficiency was evaluated by incubating the DOX loaded micelles with 4T1 breast cancer cells, and the results showed that folate-targeted micelles had higher antitumor activity than the non-targeted ones. Cellular uptake demonstrated by confocal microscopy indicated that free DOX was internalized into the nuclei of 4T1 cells, while the DOX loaded micelles were internalized in the cytoplasm. The cell uptake of the micelles was enhanced by folate with stronger fluorescence intensity in the cytoplasm due to the active FR-mediated endocytosis. These folate-conjugated glucose and pH dually responsive micelles may be a potential antitumor drug delivery system for chemotherapy of cancer.The relative cytotoxicity of FHCSPBA micelles was performed by Cell Counting Kit-8 (CCK-8) assay against L929 fibroblasts. The cells were seeded onto 96-well plates at a density of 4 × 10 4 cells per well in

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Section: Introductionmentioning

confidence: 99%

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

et al. 2016

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“…A method was proposed to improve the interface adhesion strength between the filler and the matrix of composite material by modifying the interface with catechol groups and coupling agents. [16,[40][41]42,43] At first, polydopamine (PDA) was formed by using dopamine self-polymerization functionalize BN and then dopamine-modified BN (DBN) was obtained in an alkaline environment. [44,45] After that, the secondary modification was performed, and the DBN was modified by an epoxy-functionalized silane coupling agent (KH-560) to obtain k-DBN.…”

Section: Introductionmentioning

confidence: 99%

Improved thermal and electrical properties of epoxy resin composites by dopamine and silane coupling agent modified hexagonal BN

et al. 2020

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The high thermal conductivity epoxy resin composites filled with inorganic filler can improve the low thermal conductivity of epoxy resin. However, a large number of fillers with high thermal conductivity will reduce other properties of the composites, which limits their use under high voltage, high temperature and strong mechanical force during operation. In this study, the dopamine-modified BN (DBN) and k-DBN (DBN modified by coupling agent KH-560) were prepared by employed the dopamine with catechol groups and coupling agent to modify boron nitride. The thermal conductivity, thermal stability, and dielectric properties of composites with different contents of modified fillers were studied. The results showed that surface modification improved the dispersibility of BN in the resin matrix and compatibility with the resin. Among BN/EP, DBN/EP, k-DBN/EP composites, k-DBN/EP composites had the highest thermal conductivity at the same number of additions. When the k-DBN/EP content was 30 wt%, the thermal conductivity of the composite was 0.892 W/(mÁK), which was an increase of 25.5% compared with the BN/EP composite. The appropriate amount of BN filling (20 wt%) can improve the breakdown strength of the composite material.

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“…16 Dopamine-functionalized diBCPs, 17,18 such as poly(dopamine acrylamide)-b-polystyrene (PDA-b-PS) have also been synthesized. 18 For the tailoring of surface or interfacial properties of BCPs, the combination of architecture and reactive functionalities appears to be an ideal approach. The PEO-b-PLA BCPs containing a small quantity of carboxylic acid in the PLA block were synthesized.…”

Section: Introductionmentioning

confidence: 99%

“…A amphiphilic diBCP which bears reactive trimethoxysilane groups in one segment was prepared and used as the precursor of the hybrid vesicle . Dopamine‐functionalized diBCPs, such as poly(dopamine acrylamide)‐ b ‐polystyrene (PDA‐ b ‐PS) have also been synthesized …”

Section: Introductionmentioning

confidence: 99%

4‐hydroxythiophenol grafted PS‐b‐PAA block copolymers: Preparation and formation of porous and bowl‐shaped assemblies

Zhao

et al. 2016

J Polym Sci B Polym Phys

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4-Hydroxythiophenol (HTP) grafted poly(styrene-bacrylic acid) (PS-b-PAA) block copolymers (BCPs) (PS-b-PAA-g-HTP) was synthesized using the esterification reaction between the carboxyl groups and hydroxyl groups. Self-assembly behavior of the graft copolymer in 1,4-dioxane/water was investigated. Assemblies of different morphologies, porous, and bowl-shaped structures, could be easily prepared. A possible mechanism for the formation of the porous and bowlshaped structures was discussed. The present study showed a facile method for the preparation of functionalized PS-b-PAA BCPs, which could easily self-assembly into novel structures in aqueous solution. These assemblies may be used to generate new functional materials. V C 2016 Wiley Periodicals, Inc. J.

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Diblock copolymer micelles as surface-functionalized particles and direct decoration of nanoparticles on their surface

Cited by 6 publications

References 35 publications

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

Improved thermal and electrical properties of epoxy resin composites by dopamine and silane coupling agent modified hexagonal BN

4‐hydroxythiophenol grafted PS‐b‐PAA block copolymers: Preparation and formation of porous and bowl‐shaped assemblies

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