Dibenzocyclooctadiene lignans from Kadsura angustifolia

Rubriflorin A and B, Two Novel Partially Saturated Dibenzocyclooctene Lignans from Schisandra rubriflora

“…(C(6)ÀC(7)ÀC(8)ÀC(9)) at C(5) and C(10), and two substituted aromatic moieties linked between C(15) and C(16). From the above evidence, the skeleton of 1 was deduced to be a substituted hexahydrodibenzocyclooctene lignan similar to those isolated previously from Schisandraceae plants [11] [12].…”

“…An angeloyl ( (2Z)-2-methylbut-2-enoyl) group (HÀC(3'), Me(4'), Me(5'), C(1') to C(5')) and an acetic acid ester (MeCOO) were also present (see NMR data in Table 1 (9)) value of 2.9 Hz and the NOEs (Fig. 2) between HÀC(4)/Me(17), HÀC(4)/H a À(6), HÀC(9)/HÀC(11) and HÀC(9)/Me(18) indicate a twist-boat-chair conformation of the cyclooctadiene moiety [11].…”

Ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometric procedure for qualitative and quantitative analyses of nortriterpenoids and lignans in the genus Schisandra

“…Reports have shown that the ripe fruits of the two plants exhibit similar actions, and have been primarily used as sedative, tonic agents to replenish and promote the production of body fluid, as well as tonify the kidney to relieve mental strain and for the treatment of hepatitis [2]. Although the fruits of these two plants have been accepted as two different crude drugs by the Chinese Pharmacopoeia since 2000 [2], both plants are found to be a rich source of lignans [3][4][5][6][7] and terpenoids [8][9][10][11] in particular the dibenzocylooctadiene lignans exhibiting various biological activities.…”

The mechanism of vasorelaxation induced by Schisandra chinensis extract in rat thoracic aorta

“…Schisandra chinensis fruits contain a variety of pharmacologically active lignans and the major bioactive compounds are lignans with a dibenzocyclooctadiene skeleton (Kuo et al, 1997;Chen et al, 1998;Choi et al, Abbreviations: SC, Schisandra chinensis; SCHE, hexane extract of Schisandra chinensis; MLC, myosin light chain; NO, nitric oxide; l-NAME, N G -nitro-l-arginine methyl ester; ODQ, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one; PE, phenylephrine.…”