Diazinon-induced histopathological and hematological alterations in a freshwater teleost, Ophiocephalus punctatus

Sastry, K.V.; Sharma, Kamana

doi:10.1016/0147-6513(81)90007-5

Cited by 24 publications

(13 citation statements)

References 17 publications

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“…Sastry and Sharma (1981) had reported erosion of the gastric mucosa as the only visible lesion probably caused by oxidative stress following exposure to sub-lethal concentration of diazinon in fresh water teleost fish, Ophiocephalus punctatus . However, the stomach specimens of rats in the GC group in this study showed no observable microscopic lesions.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study, mild congestion and haemorrhage, mild focal coagulative necrosis and sloughing of tubular epithelial cells in oxidative stress condition in chickens followed chronic chlorpyrifos (CPF) exposure (Kammon et al 2011). Oxidative stress was also said to cause Shrinkage of the glomerular network, necrosis of proximal tubules and ruptured distal collecting tubules (Sastry and Sharma 1981). …”

Section: Discussionmentioning

confidence: 99%

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Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate

et al. 2013

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A subchronic toxicity study was carried out to determine the glyphosate-induced histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen of rats and the attendant ameliorative effect when pretreated with zinc at the dose rate of 50 mg/kg body weight. The rats were exposed to two doses of the glyphosate (375 and 14.4 mg/kg body weight) for the period of 8 weeks which was the duration of the study, and some groups were exposed to the glyphosate after pretreatment with zinc. The histopathological changes recorded during the study were only in the rats exposed to the glyphosate at the dose rate of 375 mg/kg body weight except the vacuolation encountered in the brains and haemosiderosis in the spleens of rats exposed to zinc alone. Degenerated mucosal epithelial cells which involved the muscularis mucosa and the glands in the stomachs of rats were seen microscopically. Hepatic cells degeneration especially at the portal areas of the livers of rats was observed. The histopathological examination of the kidneys showed glomerular degeneration, mononuclear cells infiltration into the interstices of the tubules and tubular necrosis. The conspicuous changes seen in the brains were neuronal degeneration. Pancreatic acinar cells were degenerated while the spleen of the rats showed depopulated splenic cells in both the red and the white pulps. It was concluded that zinc supplementation in rats prior to glyphosate exposure ameliorated the histopathological changes observed in the stomach, liver, kidney, brain, pancreas and spleen with no observable alteration in the histoarchitecture in the organs of the zinc-supplemented rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate

et al. 2013

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“…In contrast, the organophosphate parathion produced a higher effect on 22‐d‐old larvae than in embryos of Bufo arenarum [33], indicating a higher sensitivity of older stages. The latent response concerning mortality at lower concentrations was most likely due to the longer time required to accumulate toxic levels in organs such as gills and liver [34]. It was also observed that B. melanostictus larvae were more sensitive during days 9 to 16 after the initial exposure.…”

Section: Discussionmentioning

confidence: 99%

Effects of diazinon on larvae of the Asian common toad (Bufo melanostictus, Schneider 1799)

Sumanadasa

Wijesinghe

Ratnasooriya

2008

Enviro Toxic and Chemistry

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Continuous subchronic exposure experiments were conducted to assess the effects of diazinon, an organophosphate pesticide, on the survival, growth and activity of larvae of the Asian common toad Bufo melanostictus. Two larval stages, the gill stage (Gosner stages 21 and 22) and gill-atrophy stage (Gosner stages 24 and 25), were continuously exposed to 4 microg/L, 400 mirog/L, and 10 mg/L of commercial-grade diazinon for 30 d. Treatments and untreated controls were maintained in triplicate with water changed and pesticide concentrations renewed every 3 d. Observations showed that subchronic exposure to 400 microg/L and 10 mg/L diazinon caused a significant dose-dependent increase in mortality compared to the control, regardless of the age at which larvae were exposed. One hundred percent mortality was observed in larvae exposed to 10 mg/L. No clear age-related sensitivity was evident in this study. The lethal concentrations at which 50% of the tadpoles (LC50) died during 30 d of continuous exposure were 6 and 7.5 mg/L for gill stage and gill-atrophy stage larvae, respectively. Diazinon impaired larval growth and activity. Tail abnormalities were apparent in larvae exposed to 400 microg/L and 10 mg/L of diazinon. This investigation provides the first empirical evidence of the negative effects of diazinon on the survival, growth and activity of B. melanostictus. The high degree of diazinon toxicity in this study highlights the need to consider important nontarget groups when recommending safe levels of pesticide application.

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“…Further, kidney disorder may cause the excretion of protein instead of retaining it in the blood, and it may cause depletion in the blood protein levels (Sastry & Sharma, 1981). Eventually, protein synthesize, and liver and kidney function of fish might be affected by prolonged and sublethal pesticides exposure (Saravanan, Kumar & Ramesh, 2011).…”

Section: Plasma Proteinsmentioning

confidence: 99%

Plasma proteins, hepatic enzymes, thyroid hormones and liver histopathology of Cyprinus carpio (Linnaeus, 1758) exposed to an oxadiazin pesticide, indoxacarb

et al. 2017

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Indoxacarb is a relatively new pesticide from oxadiazin class, which is used near carp ponds for agricultural purposes. Thus, the aim of this study was to determine indoxacarb effects on common carp (Cyprinus carpio). The fish were exposed to 0 (control), 0.75, 1.5 and 3 ppm of indoxacarb over 21 days and plasma biochemical characteristics and liver histopathology were examined. Exposure to indoxacarb induced fall in total protein after 21 days. Globulin increased after 7 days and then decreased after 14‐ and 21‐day exposure. Plasma alanine transaminase and aspartate transaminase activities increased in 1.5 and 3 ppm treatments after 7‐day exposure. Indoxacarb exposure significantly decreased plasma alkaline phosphatase after 7 days with no change at the second and third samplings. After 7 days, plasma T3 levels had no significant change; however, it decreased after 14 days in the 1.5 and 3 ppm treatments and also reduced after 21‐day exposure to the 3 ppm treatment compared to the control group. Plasma T4 level only decreased significantly in the 3 ppm treatment compared to the control group after 21 days. Different histopathological symptoms such as necrosis, hyperaemia, sinusoidal space extension, pyknotic nuclei, leucocyte infiltration and melanomacrophage aggregates were observed after 21‐day exposure to indoxacarb. The symptoms intensity was dependent on indoxacarb concentration. In conclusion, the present results show that indoxacarb exposure adversely affects common carp health and welfare, which consequently may induce serious problems in this species aquaculture.

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Diazinon-induced histopathological and hematological alterations in a freshwater teleost, Ophiocephalus punctatus

Cited by 24 publications

References 17 publications

Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate

Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate

Effects of diazinon on larvae of the Asian common toad (Bufo melanostictus, Schneider 1799)

Plasma proteins, hepatic enzymes, thyroid hormones and liver histopathology of Cyprinus carpio (Linnaeus, 1758) exposed to an oxadiazin pesticide, indoxacarb

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