Diazinon and Porphyria Cutanea Tarda

In this preliminary study on sea birds we propose the use of porphyrins in excreta as a biomarker of exposure to contaminants. Samples of excreta were obtained from colonies of brown pelicans (Pelecanus occidentalis thagus), neotropic cormorants (Phalacrocorax olivaceus), and kelp gulls (Larus dominicanus) in three areas of the south coast of Chile with different human impact (Tubul, Talcahuano, and Valdivia). They were analyzed for porphyrin content (copro-, uro-, and protoporphyrins and total porphyrins) by a rapid fluorimetric method and by HPLC. The main outcomes of the study were: (a) kelp gulls and neotropic cormorants living in areas with high human impact showed a clear capacity to accumulate and eliminate porphyrins in the excreta; (b) species-related accumulation capacities are likely, as shown by the different levels found in different species living in the same area; (c) the porphyrin profile obtained by fluorimetry and HPLC showed a higher percentage of protoporphyrin than the other porphyrins; (d) although the fluorimetric method of Grandchamp is semiquantitative, it was found to be sensitive enough to detect differences in samples from field studies. The positive results of this preliminary study make it possible to propose this nondestructive method for a variety of field applications.

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Porphyrin Levels in Excreta of Sea Birds of the Chilean Coasts as Nondestructive Biomarker of Exposure to Environmental Pollutants

Casini

Fossi

Gavilán

et al. 2001

Archives of Environmental Contamination and Toxicology

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Separation of impurities in diazinon preparations and their effect on porphyrin biosynthesis in tissue culture

Nichol

Elsbury

Elder³

et al. 1982

Biochemical Pharmacology

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The site of inhibition of porphyrin biosynthesis by an isomer of diazinon in rats

Nichol

Elsbury

Angel

et al. 1983

Biochemical Pharmacology

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Diazinon and Porphyria Cutanea Tarda

Cited by 11 publications

References 3 publications

Porphyrin Levels in Excreta of Sea Birds of the Chilean Coasts as Nondestructive Biomarker of Exposure to Environmental Pollutants

Porphyrin Levels in Excreta of Sea Birds of the Chilean Coasts as Nondestructive Biomarker of Exposure to Environmental Pollutants

Separation of impurities in diazinon preparations and their effect on porphyrin biosynthesis in tissue culture

The site of inhibition of porphyrin biosynthesis by an isomer of diazinon in rats

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