Diazepam-like effects of a fish protein hydrolysate (Gabolysat PC60) on stress responsiveness of the rat pituitary-adrenal system and sympathoadrenal activity

Abstract

Present data suggest diazepam-like effects of PC60 on stress responsiveness of the rat pituitary adrenal axis and the sympathoadrenal activity as well as GABA content of the hippocampus and the hypothalamus under resting and stress conditions. These effects of PC60 agree with anxiolytic properties of this nutritional supplement, previously reported in both rats and humans.

Food-derived peptidic antioxidants: A review of their production, assessment, and potential applications

“…Various food protein sources including fish, milk, egg, soybean, wheat and zein, among others, have been exploited to produce antioxidative protein hydrolysates and peptides (Table 1). Fish and other seafood sources have particularly gained much interest as potential antioxidative peptide sources mainly due to the abundance of raw materials in the form of processing discards and underutilized species, in conjunction with research findings indicating an array of other biological activities for fish protein hydrolysates and specific peptide sequences derived from these sources such as antihypertensive, immunomodulatory, neuroactive, antimicrobial, mineral and hormonal regulating properties (Bernet, Montel, Noel, & Dupouy, 2000;Duarte, Vinderola, Ritz, Perdigó n, & Matar, 2006;Je, Qian, Byun, & Kim, 2007;Jun, Park, Jung, & Kim, 2004;Jung et al, 2006;Liu et al, 2008;Murray & Fitzgerald, 2007). Table 1 also lists different enzymes and/or processes that have been used in making these protein hydrolysates and peptides.…”

Assessment of noise-induced fear and anxiety in dogs: Modification by a novel fish hydrolysate supplemented diet

“…Analytic testing ensures inter-batch standardization. The 55 PC60 fish hydrolysate (cod and mackerel) has been found to have benzodiazpepine-like effects on the 56 hypothalamic-pituitary-adrenal (HPA) axis, sympathoadrenal activity and levels of gamma-aminobutyric 57 acid (GABA) in the hippocampus and the hypothalamus (Bernet et al, 2000). Stabilium 200, a derivative 58 of PC60, was found to reduce anxiety in humans (Dorman et al, 1995) and to improve memory and 59 learning performances in rats (Le Poncin, 1996a) and humans (Le Poncin, 1996b were divided into two cohorts, which were tested on successive days.…”

Enzymes in Fish Processing

“…48,50,72 Additionally, neuroactive peptides and immunoactive peptides have been found in fish protein hydrolyzate. 73,74 Bioactive peptides can be released from the parent proteins by proteolytic enzymes during gastrointestinal digestion or during food processing. 75 Antioxidative peptides can serve as a natural antioxidant to prevent free radical-mediated modification of DNA, proteins, lipids as well small cellular molecules which are associated with a number of pathological processes.…”