Diazepam concentrations in parotid saliva, mixed saliva, and plasma

Abstract

The concentration of diazepam in the plasma and saliva of 9 normal human subjects receiving a single oral dose of diazepam (10 mg) over an 8-hr The secretion of drugs into saliva has been the subject of many investigations in man. [2][3][4][5][6]11 Both parotid saliva and mixed saliva have been used to evaluate the usefulness of this biologic fluid in predicting blood concentrations of drugs. The exchange of drugs between blood and saliva is determined by many variables, including protein binding, degree of lipid solubility, extent of ionization, and molecular size of the particular drug.Diazepam is a long-acting lipophilic drug, primarily undissociated at physiologic pH, which has a high affinity for plasma proteins,9 The remaining nonprotein bound (free) form of this drug distributes widely throughout the body, particularly into the central nervous system, The free form of diazepam in the central nervous system has been quantitated in human cerebrospinal fluid.9 Little or no information, however, has been published on the availability of the free form (unbound) of diazepam in human salivary secretions.

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Prevalence of driving with blood drug concentrations above proposed new legal limits in Norway: Estimations based on drug concentrations in oral fluid

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