Diazepam-atenolol combination antagonizes aminophylline-induced convulsions and lethality in mice

Chugh, Yati; Chakrabarti, Amitava; Sharma, Pankaj

doi:10.1016/0014-2999(91)90650-f

“…Alprazolam was given at 5 mg/kg, also after pilot testing. Sympathetic antagonists' doses were based on previous studies [27,[30][31][32][33].…”

Section: Methodsmentioning

confidence: 99%

“…An experiment was conducted for each antagonist: 5 mg/kg of prazocin [27][28][29][30], 5 mg/kg of atenolol [31,32], and 1 mg/kg of propranolol [27,30,31,33]. In each experiment, the mice were divided into six groups (n=7).…”

Section: Methodsmentioning

confidence: 99%

The Effect of Sympathetic Antagonists on the Antidepressant Action of Alprazolam

Ra

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Sm

²

,

Ea

³

et al. 2008

Libyan Journal of Medicine

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Alprazolam is an anti-anxiety drug shown to be effective in the treatment of depression. In this study, the effect of sympathetic receptor antagonists on alprazolam–induced antidepressant action was studied using a mouse model of forced swimming behavioral despair. The interaction of three sympathetic receptor antagonists with benzodiazepines, which may impact the clinical use of alprazolam, was also studied. Behavioral despair was examined in six groups of albino mice. Drugs were administered intraperitoneally. The control group received only a single dose of 1% Tween 80. The second group received a single dose of alprazolam, and the third group received an antagonist followed by alprazolam. The fourth group was treated with imipramine, and the fifth group received an antagonist followed by imipramine. The sixth group was treated with a single dose of an antagonist alone (atenolol, a β1-selective adrenoceptor antagonist; propranolol, a non selective β-adrenoceptor antagonist; and prazocin, an α1-adrenoceptor antagonist). Results confirmed the antidepressant action of alprazolam and imipramine. Prazocin treatment alone produced depression, but it significantly potentiated the antidepressant actions of imipramine and alprazolam. Atenolol alone produced an antidepressant effect and potentiated the antidepressant action of alprazolam. Propranolol treatment alone produced depression, and antagonized the effects of alprazolam and imipramine, even producing depression in combined treatments.In conclusion, our results reveal that alprazolam may produce antidepressant effects through the release of noradrenaline, which stimulates β2 receptors to produce an antidepressant action. Imipramine may act by activating β2 receptors by blocking or down-regulating β1 receptors.

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“…Chugh et al reported a similar effect where diazepam administration was effective at reducing aminophylline‐induced seizures in mice but offered no protection against mortality. However, when diazepam (10 mg·kg −1 ) was coadministered with atenolol (5 mg·kg −1 ), it produced complete protection against convulsions and sudden death . The clinical significance of the anticonvulsant effect of the β‐blockers is controversial.…”

Section: Discussionmentioning

confidence: 99%

“…However, when diazepam (10 mgÁkg À1 ) was coadministered with atenolol (5 mgÁkg À1 ), it produced complete protection against convulsions and sudden death. 32 The clinical significance of the anticonvulsant effect of the b-blockers is controversial. In audiogenic seizure mice, predosing with the lipophilic propranolol (30-50 mgÁkg À1 , i.p.)…”

Section: Discussionmentioning

confidence: 99%

Improved cardiac outcomes with combined atenolol and diazepam intervention in seizure

Read

¹

,

Millen

²

,

McCann

³

et al. 2018

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“…An experiment was conducted for each antagonist: 5 mg/kg of prazocin [27–30], 5 mg/kg of atenolol [31, 32], and 1 mg/kg of propranolol [27, 30, 31, 33]. In each experiment, the mice were divided into six groups (n=7).…”

Section: Methodsmentioning

confidence: 99%

The Effect of Sympathetic Antagonists on the Antidepressant Action of Alprazolam

Ra

¹

,

Sm

²

,

Alghzewi

³

et al. 2008

View full text Add to dashboard Cite

Alprazolam is an anti-anxiety drug shown to be effective in the treatment of depression. In this study, the effect of sympathetic receptor antagonists on alprazolam–induced antidepressant action was studied using a mouse model of forced swimming behavioral despair. The interaction of three sympathetic receptor antagonists with benzodiazepines, which may impact the clinical use of alprazolam, was also studied. Behavioral despair was examined in six groups of albino mice. Drugs were administered intraperitoneally. The control group received only a single dose of 1% Tween 80. The second group received a single dose of alprazolam, and the third group received an antagonist followed by alprazolam. The fourth group was treated with imipramine, and the fifth group received an antagonist followed by imipramine. The sixth group was treated with a single dose of an antagonist alone (atenolol, a β1-selective adrenoceptor antagonist; propranolol, a non selective β-adrenoceptor antagonist; and prazocin, an α1-adrenoceptor antagonist). Results confirmed the antidepressant action of alprazolam and imipramine. Prazocin treatment alone produced depression, but it significantly potentiated the antidepressant actions of imipramine and alprazolam. Atenolol alone produced an antidepressant effect and potentiated the antidepressant action of alprazolam. Propranolol treatment alone produced depression, and antagonized the effects of alprazolam and imipramine, even producing depression in combined treatments.In conclusion, our results reveal that alprazolam may produce antidepressant effects through the release of noradrenaline, which stimulates β2 receptors to produce an antidepressant action. Imipramine may act by activating β2 receptors by blocking or down-regulating β1 receptors.

show abstract

Diazepam-atenolol combination antagonizes aminophylline-induced convulsions and lethality in mice

Cited by 11 publications

References 4 publications

The Effect of Sympathetic Antagonists on the Antidepressant Action of Alprazolam

The Effect of Sympathetic Antagonists on the Antidepressant Action of Alprazolam

Improved cardiac outcomes with combined atenolol and diazepam intervention in seizure

The Effect of Sympathetic Antagonists on the Antidepressant Action of Alprazolam

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