Diazepam and Breast-Feeding

Patrick, Marguerite J.; Tilstone, W. J.; Reavey, P. C.

doi:10.1016/s0140-6736(72)90216-4

Cited by 88 publications

(23 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kanto, 1972) and there has been one report of lethargy and weight loss with EEG evidence of sedation in a breast-fed infant of a mother taking 30 mg diazepam daily (Patrick et al, 1972). To our knowledge, there is only one previous report of oxazepam excretion in human milk (Wretlind, 1987).…”

Section: Introductionmentioning

confidence: 98%

Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.

Dusci¹,

Good²,

Hall³

et al. 1990

Brit J Clinical Pharma

View full text Add to dashboard Cite

The excretion of diazepam, N-desmethyldiazepam, temazepam and oxazepam in breast milk was studied during withdrawal of a 22-year-old patient from combined high dose diazepam and oxazepam therapy. Concentrations of these benzodiazepines in plasma from both the woman and her nursing infant (1 year old) were also documented. Diazepam, N-desmethyldiazepam, temazepam and oxazepam were found in the maternal plasma and milk with mean milk: plasma ratios of 0.2, 0.13, 0.14 and 0.10 respectively. It was calculated on a mg kg-1 basis that the infant received some 4.7% of the maternal dose. Diazepam could not be detected in the infant's plasma, but low levels of N-desmethyldiazepam (20 and 21 ,ug 1-1), temazepam (7 ,ug 1-1) and oxazepam (7.5 and 9.6 ,ug 1-1) were present. The infant showed no overt physical or mental symptoms of benzodiazepine intoxication.

show abstract

Section: Introductionmentioning

confidence: 98%

Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.

Dusci¹,

Good²,

Hall³

et al. 1990

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…However, medicine taken by the mother may be transferred into breast milk to a significant degree, resulting in unnecessarily exposure of the infant to pharmacological agents. In the cases of certain drugs, adverse reactions in infants have been demonstrated after breast feeding (Patrick et al, 1972;Schimmel et al, 1989). Under such situations, mothers must choose between giving up breast feeding and abstaining from the medication.…”

Section: Introductionmentioning

confidence: 99%

Analysis and Prediction of Drug Transfer into Human Milk Taking into Consideration Secretion and Reuptake Clearances across the Mammary Epithelia

Koshimichi

Ito

Hisaka³

et al. 2011

Drug Metab Dispos

View full text Add to dashboard Cite

ABSTRACT:Medication use during lactation is a matter of concern due to unnecessary exposure of infants to drugs. Although some studies have predicted the extent of drug transfer into milk from physicochemical parameters, drug concentration-time profiles in milk have not been predicted or even analyzed yet. In the present study, a drug transfer model was constructed by defining secretion and reuptake clearances (CL sec and CL re , respectively) between milk and plasma based on unbound drug concentrations.

show abstract

“…Breast feeding has its inherent Correspondence: Dr P. J. McNamara, Division of Pharmacology and Experimental Therapeutics, University of Kentucky, Lexington, Ky 40536 advantages in terms of milk composition, immunoprotection, and bonding [6]. Benzodiazepines such as diazepam, oxazepam, lorazepam, lormetazepam, quazepam, midazolam, nitrazepam, flunitrazepam, metaclazepam and lormetazepam have been found in breast milk to varying degrees, with milk:serum (M/S) ratios ranging from 0.1-3 [7][8][9][10][11][12][13][14][15][16]. These reports show that neonatal levels were generally low and not associated with obvious adverse effects, with the exception of sedation [16].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics in lactating women: prediction of alprazolam transfer into milk.

Desai

et al. 1995

Brit J Clinical Pharma

View full text Add to dashboard Cite

1 Alprazolam, a triazolobenzodiazepine, is extensively prescribed for the treatment of anxiety disorders, which predominantly affect women of child-bearing age. The purpose of the present study was to assess the pharmacokinetics of alprazolam and its two hydroxylated metabolites: 4-hydroxy-alprazolam and a-hydroxy-alprazolam in lactating human volunteers and to test the predictability of four recently reported models for drug transfer into milk based on physicochemical properties. 2 Multiple milk and serum samples in eight lactating subjects were collected up to 36 h following single oral doses of 0.5 mg alprazolam; suckling of the infant was discontinued after drug administration. 4-Hydroxy-alprazolam was the predominant metabolite in serum samples while a-hydroxy-alprazolam was not detected.

show abstract

Diazepam and Breast-Feeding

Cited by 88 publications

References 2 publications

Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.

Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.

Analysis and Prediction of Drug Transfer into Human Milk Taking into Consideration Secretion and Reuptake Clearances across the Mammary Epithelia

Pharmacokinetics in lactating women: prediction of alprazolam transfer into milk.

Contact Info

Product

Resources

About