Diazachlorin and diazabacteriochlorin for one- and two-photon photodynamic therapy

Abstract

Diazachlorin and diazabacteriochlorin were prepared and their activity for photodynamic therapy was investigated.

Molecular complexes and main-chain organometallic polymers based on Janus bis(carbenes) fused to metalloporphyrins

“…51,52 Singlet oxygen ( 1 O2) is produced from this triplet excited state by triplet-triplet energy transfer with triplet oxygen ( 3 O2). 53 Because it is a very strong oxidative agent, 1 O2 is able to oxidize a great number of surrounding molecules. Consequently, porphyrins can be used to design photoactive materials for photocatalysis, biomedicine or water remediation.…”

Biological Assessment of Laser-Synthesized Silicon Nanoparticles Effect in Two-Photon Photodynamic Therapy on Breast Cancer MCF-7 Cells

“…Moreover, thanks to the non-linear absorption, the PDT damage can be dramatically limited to the tumor area with a high spatiotemporal resolution [7][8][9]. Among popular theranostic tools used in TPE-PDT, such as organic molecules and quantum dots [10][11][12], nanoengineered particles based on silicon and their derivative formulations have gained significant interest. Indeed, silicon element is one of the most abundant mineral on earth with distinctive physiological activities such as bone mineralization and transduction mechanism [13][14][15][16][17].…”

“…Among popular theranostic tools used in TPE-PDT, such as organic molecules and quantum dots [ 10 , 11 , 12 ], nanoengineered particles based on silicon and their derivative formulations have gained significant interest. Indeed, silicon element is one of the most abundant mineral on earth with distinctive physiological activities such as bone mineralization and transduction mechanism [ 13 , 14 , 15 , 16 , 17 ].…”

Effects of the Peripheral Substituents, Central Metal, and Solvent on the Photochemical and Photophysical Properties of 5,15‐Diazaporphyrins

“…Independently, Shinokubo and co-workers reported the in vitro and in vivo activity of the free bases of β-unsubstituted DAP 1H 2 , [8] 5,15-diazachlorin P3, [9] and 5,15diazabacteriochlorin P4 [9] (Figure 1) in one-and two-photon PDT. [10] Despite having no hydrophilic substituents, a sufficient amount of P4 was internalized into the cell, and its excellent PDT performance was observed under irradiation with NIR light.…”

“…During our ongoing study on β‐functionalized DAPs, we recently reported that DAPs bearing diphenylamino ( P2 ), phenoxy, or diethoxyphosphoryl group efficiently generated 1 O 2 under irradiation of visible or NIR light ( Φ Δ =0.92–0.99 in toluene). Independently, Shinokubo and co‐workers reported the in vitro and in vivo activity of the free bases of β‐unsubstituted DAP 1H 2 , 5,15‐diazachlorin P3 , and 5,15‐diazabacteriochlorin P4 (Figure ) in one‐ and two‐photon PDT . Despite having no hydrophilic substituents, a sufficient amount of P4 was internalized into the cell, and its excellent PDT performance was observed under irradiation with NIR light.…”