Abstract:Antibody-drug conjugates (ADCs) are an ew class of therapeutics that combine the lethality of potent cytotoxic drugs with the targeting ability of antibodies to selectively deliver drugs to cancer cells.Inthis study we showfor the first time the synthesis of ar eactive-oxygen-species (ROS)-responsive ADC (VL-DAB31-SN-38) that is highly selective and cytotoxic to B-cell lymphoma (CLBL-1 cell line,IC 50 value of 54.1 nM). The synthesis of this ADC was possible due to the discovery that diazaborines (DABs) are av… Show more
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